Diets rich in soy protect against prostate cancer. Then again, they don't.
This paradoxical finding came from a study of 43,509 Japanese men. For some soy isoflavones in the diet decreased the risk of localized prostate cancer, but at the same time soy containing miso soup increased the risk of advanced prostate cancer.
So reported Norie Kurahashi, M.D., of the National Cancer Center of Japan, and colleagues, in the March issue of Cancer Epidemiology, Biomarkers & Prevention.
"The present findings provide no clear understanding of when or how localized cancer will develop to aggressive cancer, and of the related effect of isoflavones," said Dr. Kurahashi.
The investigators recommended that Japanese men continue their high consumption of soy from foods, but they discouraged the use of supplements.
The investigators hypothesized that soy in general, and its isoflavones genistein and daizden in particular, may attenuate but not prevent the progression of latent prostate cancer. Soy isoflavones are estrogen mimics and strong antioxidants in vitro, and appear to be protective against cancer in animal models.
http://www.medpagetoday.com/Urology/ProstateCancer/tb1/5272
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