COLUMBUS, Ohio -- Inherent gender differences – instead of more sun exposure – may be one reason why men are three times more likely than women to develop certain kinds of skin cancer, say researchers at Ohio State University Medical Center.
Squamous cell carcinoma is the second most common form of skin cancer, accounting for nearly 200,000 new cases in the United States each year. While occurring more often than melanoma, squamous cell carcinoma is not nearly as worrisome. Still, it can be lethal in some patients, especially those with suppressed immune systems, including transplant recipients or people who are HIV-positive.
Many studies have shown that the risk of squamous cell carcinoma increases with greater exposure to the sun. For years, investigators assumed that lifestyle had a lot to do with the disparity in the incidence of SCC – believing that men spend more time outside and are less likely to use sun protection than women.
While that may be true, scientists at Ohio State have shown that there may be another, even more critical factor involved – gender-linked differences in the amount of naturally occurring antioxidants in the skin.
The study appears in the April 1 issue of Cancer Research.
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