Gene mutation tied to early-onset Parkinson disease

By Will Boggs, MDFri Sep 28, 3:36 PM ET
People with a certain gene mutation are more likely to get Parkinson's disease early -- before the age of 50 -- compared to those without the gene abnormality, according to a new study.
Dr. Lorraine N. Clark, from Columbia University, New York, and colleagues analyzed the genes of 278 people with Parkinson's disease and 179 people without the disease.
They report that 14 percent of the people with Parkinson's disease carried mutations in the glucocerebrosidase (GBA) gene compared to only five percent of people without the disease.
The gene abnormality was found in 22 percent of people who were diagnosed with Parkinson's disease before age 50 compared to 10 percent of the people with disease onset after age 50.
"Our results confirm that GBA mutations are risk factors for Parkinson's disease and may lead to getting the disease at a younger age," Clark said in a statement. "We found those people with GBA mutations developed Parkinson's disease nearly two years earlier than people without the gene abnormality."
The researchers also looked at how Jewish ancestry affected the likelihood of getting Parkinson's disease at an earlier age since some studies have found people with Jewish ancestry are more likely to have GBA mutations.
Of those with Parkinson's disease, Clark's team found the gene abnormality in 17 percent of subjects with Jewish ancestry compared to only eight percent of those without Jewish ancestry, suggesting that it may be an important risk factor in people with Jewish ancestry.
SOURCE: Neurology September 18, 2007.