Cardiac Score Predicts Death in Chronic Kidney Disease

TIMI score effective in patients with kidney dysfunction and chest pain or a heart attack

09 june 2009-- A risk stratification score is effective in predicting mortality risk across a range of kidney function in patients with chest pain or a heart attack, according to a study in the June 1 issue of the American Journal of Cardiology.

Usman Baber, M.D., and colleagues from Mount Sinai Hospital in New York City examined the prognostic value of the Thrombolysis In Myocardial Infarction (TIMI) risk score in 6,940 patients with moderate to advanced kidney disease and unstable angina pectoris or non-ST elevation myocardial infarction.

During a median follow-up of 3.2 years, the researchers observed 813 deaths. The adjusted mortality hazard ratio for the highest TIMI scores compared with lower scores was as high as 4.26 in patients with an estimated glomerular filtration rate (eGFR) of 60 or greater, as high as 1.77 for patients with an eGFR of 30 to 59, as high as 2.83 for patients with an eGFR less than 30, and as high as 3.67 for patients on dialysis.

"Our study demonstrates that the TIMI risk score, a conventional algorithm that does not include nontraditional risk factors, discriminates mortality risk in patients with advanced chronic kidney disease and on dialysis," Baber and colleagues conclude.

Abstract
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