Light-to-moderate drinking good for your heart, researchers say

People who drink wine, liquor or beer regularly are less prone to heart failure and heart attacks than those who rarely or never drink. Three to five drinks a week can be good for your heart.
Drinking a little alcohol every day may be part of a healthy lifestyle, according to Imre Janszky, a professor of social medicine at the Norwegian University of Science and Technology (NTNU). He says alcohol does more good than harm for your heart when consumed in moderation.

20 feb 2016--And, Janszky says, it doesn't matter much whether you drink wine, liquor or beer.
"It's primarily the alcohol that leads to more good cholesterol, among other things. But alcohol can also cause higher blood pressure. So it's best to drink moderate amounts relatively often," he says
.
Decreased risk with each additional serving

Along with a number of colleagues from NTNU and the Karolinska Institute in Stockholm, Janszky has published two studies regarding the relationship between alcohol and heart health. One, published in the January 15 issue of the International Journal of Cardiology, is about heart failure. The second, from September 2015, is on acute myocardial infarction (AMI), and has been published in the Journal of Internal Medicine.
In both cases, research shows that people who regularly drink alcohol have better cardiovascular health than those who consume little or no alcohol.
The studies showed that those who drank three to five drinks per week were 33 per cent less prone to heart failure than those who abstained or drank infrequently. In the case of heart attacks, the risk appears to be reduced by 28 percent with each additional one-drink increment.
This does not surprise the researchers at all.
A majority of researchers worldwide seem to think three to five drinks a week can be good for your heart.

Different drinking patterns

"The relationship between alcohol and heart health has been studied in many countries, including the USA and southern European nations. The conclusions have been the same, but the drinking patterns in these countries are very different than in Norway. In countries like France and Italy, very few people don't drink," says Janszky. "It raises the question as to whether earlier findings can be fully trusted, if other factors related to non-drinkers might have influenced research results. It may be that these are people who previously had alcohol problems, and who have stopped drinking completely," he says.
For this reason, the researchers wanted to examine the theory with a Norwegian population where a significant population drinks rarely or not at all. In the myocardial infarction study, 41 per cent of participants reported that they did not drink at all or that they consumed less than half of one alcoholic beverage per week.
Both studies are based on the longitudinal HUNT 2 Nord-Trøndelag Health Study conducted between 1995 and 1997.

The greater the drinking frequency, the lower the risk

The study, which looked at the relationship between heart failure and alcohol, followed 60,665 participants who enrolled in the HUNT study between 1995-1997 and who had no incidence of heart failure at that time. Of those, 1588 of them developed heart failure during the period of the study, which ended in 2008. The risk was highest for those who rarely or never drank alcohol, and for those who had an alcohol problem.
The more often participants consumed alcohol within normal amounts, the lower their risk of heart failure turned out to be. Those who drank five or more times a month had a 21 per cent lower risk compared to non-drinkers and those who drank little, while those who drank between one and five times a month had a two per cent lower risk.

Drinking isn't necessary for a healthy heart

"I'm not encouraging people to drink alcohol all the time. We've only been studying the heart, and it's important to emphasize that a little alcohol every day can be healthy for the heart. But that doesn't mean it's necessary to drink alcohol every day to have a healthy heart," says Janszky.
In the heart attack study, 58,827 participants were categorized by how much and how often they drank. 2966 of the participants experienced an acute myocardial infarction (AMI) between 1995 and the end of 2008. The adjusted analyses showed that each additional one-drink increment decreased the risk of AMI by 28 percent.

Alcohol may increase other problems

The researchers stressed that few participants in the study drank particularly much, so they cannot conclude that high alcohol intake protects against heart attack or heart failure. They also encourage looking at the findings in a larger context, since the risk of a number of other diseases and social problems can increase as a result of higher alcohol consumption.
For example, the researchers observed that the risk of dying from various types of cardiovascular disease increased with about five drinks a week and up, while those who drank more moderate amounts had the lowest risk. High alcohol consumption was also strongly associated with an increased risk of death from liver disease.

More information: Katalin Gémes et al. Light-to-moderate drinking and incident heart failure—the Norwegian HUNT study, International Journal of Cardiology (2016). DOI: 10.1016/j.ijcard.2015.10.179 K.

Gémes et al. Alcohol consumption is associated with a lower incidence of acute myocardial infarction: results from a large prospective population-based study in Norway, Journal of Internal Medicine(2015). DOI: 10.1111/joim.12428


Provided by Norwegian University of Science and Technology

A gene mutation for excessive alcohol drinking found

UK researchers have discovered a gene that regulates alcohol consumption and when faulty can cause excessive drinking. They have also identified the mechanism underlying this phenomenon.

27 nov 2013--The study showed that normal mice show no interest in alcohol and drink little or no alcohol when offered a free choice between a bottle of water and a bottle of diluted alcohol.

However, mice with a genetic mutation to the gene Gabrb1 overwhelmingly preferred drinking alcohol over water, choosing to consume almost 85% of their daily fluid as drinks containing alcohol.

The consortium of researchers from five UK universities – Imperial College London, Newcastle University, Sussex University, University College London and University of Dundee – and the MRC Mammalian Genetics Unit (MGU) at Harwell, funded by the Medical Research Council (MRC), Wellcome Trust and ERAB, publish their findings today in Nature Communications.

Dr Quentin Anstee, Consultant Hepatologist at Newcastle University, joint lead author said: "It's amazing to think that a small change in the code for just one gene can have such profound effects on complex behaviours like alcohol consumption.

"We are continuing our work to establish whether the gene has a similar influence in humans, though we know that in people alcoholism is much more complicated as environmental factors come into play. But there is the real potential for this to guide development of better treatments for alcoholism in the future."

Working at the MRC Mammalian Genetics Unit, a team led by Professor Howard Thomas from Imperial College London introduced subtle mutations into the genetic code at random throughout the genome and tested mice for alcohol preference. This led the researchers to identify the gene Gabrb1 which changes alcohol preference so strongly that mice carrying either of two single base-pair point mutations in this gene preferred drinking alcohol (10% ethanol v/v - about the strength of wine), over water.

The group showed that mice carrying this mutation were willing to work to obtain the alcohol-containing drink by pushing a lever and, unlike normal mice, continued to do so even over long periods. They would voluntarily consume sufficient alcohol in an hour to become intoxicated and even have difficulty in coordinating their movements.

The cause of the excessive drinking was tracked down to single base-pair point mutations in the gene Gabrb1, which codes for the beta 1 subunit, an important component of the GABAA receptor in the brain. This receptor responds to the brain's most important inhibitory chemical messenger (GABA) to regulate brain activity.

The researchers found that the gene mutation caused the receptor to activate spontaneously even when the usual GABA trigger was not present.

These changes were particularly strong in the region of the brain that controls pleasurable emotions and reward, the nucleus accumbens, as Dr Anstee explains: "The mutation of the beta1 containing receptor is altering its structure and creating spontaneous electrical activity in the brain in this pleasure zone, the nucleus accumbens. As the electrical signal from these receptors increases, so does the desire to drink to such an extent that mice will actually work to get the alcohol, for much longer than we would have expected."

Professor Howard Thomas said: "We know from previous human studies that the GABA system is involved in controlling alcohol intake. Our studies in mice show that a particular subunit of GABAA receptor has a significant effect and most importantly the existence of these mice has allowed our collaborative group to investigate the mechanism involved. This is important when we come to try to modify this process first in mice and then in man."

Initially funded by the MRC, the 10-year project to find genes affecting alcohol consumption was led by Professor Howard Thomas from Imperial College London and initiated at the MRC Mammalian Genetics Unit. The consortium now involves researchers at five UK universities - Imperial College London, Newcastle University, Sussex University, University College London and the University of Dundee. Senior investigators are Dr Quentin Anstee at Newcastle University and Dr Susanne Knapp at Imperial College London (joint lead authors); Professor Dai Stephens at Sussex University; Professor Trevor Smart at University College London; Professor Jeremy Lambert and Dr Delia Belelli at the University of Dundee; and Professor Steve Brown at the MRC Mammalian Genetics Unit.

Professor Hugh Perry, Chair of the MRC's Neurosciences and Mental Health Board, said: "Alcohol addiction places a huge burden on the individual, their family and wider society. There's still a great deal we don't understand about how and why consumption progresses into addiction, but the results of this long-running project suggest that, in some individuals, there may be a genetic component. If further research confirms that a similar mechanism is present in humans, it could help us to identify those most at risk of developing an addiction and ensure they receive the most effective treatment."

More information: Anstee, Q. M. et al. Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition. Nat. Commun. 4:2816 DOI: 10.1038/ncomms3816 (2013).

Provided by Newcastle University

Over-65s are frequent binge drinkers: US study

Binge drinking is more common in the United States than previously thought, particularly among young adults, though the most frequent offenders are over 65, said a US government study on Tuesday.

14 jan 2011--One in six Americans, or 17.1 percent of the population, binge drinks, defined as consuming five or more alcoholic beverages in a sitting for men and four or more among women, said the Centers for Disease Control and Prevention.

The latest data for 2010 is an increase over the CDC's report on the same topic for 2009, which said about 15 percent of US adults, or 33 million Americans, binge drink, a rate that had stayed the same for more than 15 years.

While the most common age group among the 38 million American who binge drink was 18-34, those who reported doing it most often were over 65, said the CDC's Vital Signs report, which also warned of the health and safety risks of high alcohol use.

Seniors who binge drink reported doing so 5.5 times per month, compared to an average of four times a month among the rest of the binge-drinking population.

The 18-24 age group had the highest amount of binge drinkers (28.2 percent) in their ranks and tended to drink the most -- 9.3 drinks -- in each setting. The age group 25-34 was a close second (27.9 percent).

"Binge drinking by adults has a huge public health impact, and influences the drinking behavior of underage youth by the example it sets," said CDC substance abuse and mental health services administrator Pamela Hyde.

"We need to reduce binge drinking by adults to prevent the immediate and long-term effects it has on the health of adults and youth."

The data was collected by a randomized phone survey in 48 states and the US capital region. This year, it also included cell phones, which likely resulted in a higher number of young people's participation.

The survey found that binge drinking was most common among people who earned $75,000 or more a year in household income, but those who earned less than $25,000 a year went on binges more frequently.

Low-income binge drinkers tended to consume excessive alcohol five times per month and 8.5 drinks each time.

Whites and Hispanics were more likely to binge drink than blacks. Also, men were more likely to binge drink than women.

"Binge drinking causes more than half of the 80,000 deaths and three quarters of the $223.5 billion in economic costs caused by excessive drinking," said the report.

"Drinking too much contributes to over 54 different injuries and diseases, including car crashes, violence, and sexually-transmitted diseases."

The CDC said that raising the price of alcohol, limiting the days and hours when it can be sold, and restricting the number of liquor licenses offered in a given geographic area could help cut down on binge drinking.

More information: CDC report: http://www.cdc.gov/vitalsigns

Moderate drinking protects against Alzheimer's and cognitive impairment

Moderate social drinking significantly reduces the risk of dementia and cognitive impairment, according to an analysis of 143 studies by Loyola University Chicago Stritch School of Medicine researchers.

20 aug 2011--Researchers reviewed studies dating to 1977 that included more than 365,000 participants. Moderate drinkers were 23 percent less likely to develop cognitive impairment or Alzheimer's disease and other forms of dementia.

Wine was more beneficial than beer or spirits. But this finding was based on a relatively small number of studies, because most papers did not distinguish among different types of alcohol.

Results are reported in the journal Neuropsychiatric Disease and Treatment. The authors are Edward J. Neafsey, PhD. and Michael A. Collins, PhD., professors in the Department of Molecular Pharmacology and Therapeutics.

Heavy drinking (more than 3 to 5 drinks per day) was associated with a higher risk of cognitive impairment and dementia, but this finding was not statistically significant.

"We don't recommend that nondrinkers start drinking," Neafsey said. "But moderate drinking -- if it is truly moderate -- can be beneficial." Moderate drinking is defined as a maximum of two drinks per day for men and 1 drink per day for women.

Among the studies reviewed, 74 papers calculated the ratios of risk between drinkers and non-drinkers, while 69 papers simply stated whether cognition in drinkers was better, the same or worse than cognition in nondrinkers. Neafsey and Collins did a meta-analysis of the studies that calculated risk ratios and found that moderate drinkers were 23 percent less likely to develop dementia or cognitive decline.

Other findings:

• The protective effect of moderate drinking held up after adjusting for age, education, sex and smoking.
• There was no difference in the effects of alcohol on men and women.
• The beneficial effect of moderate drinking was seen in 14 of 19 countries, including the United States. In 3 of the remaining 5 countries, researchers also found a benefit, but it was not strong enough to be statistically significant.
• The findings were similar across different types of studies (longitudinal cohort studies, case-control studies and cross-sectional studies).

It is unknown why moderate drinking can have a beneficial effect. One theory suggests that the well-known cardiovascular benefits of moderate alcohol consumption, such as raising good HDL cholesterol, also can improve blood flow in the brain and thus brain metabolism.

A second possible explanation involves "sick quitters." According to this theory, nondrinkers have a higher risk of cognitive impairment and dementia because the group includes former heavy drinkers who damaged their brain cells before quitting. But the analysis by Neafsey and Collins did not support this explanation. They found that in studies that excluded former heavy drinkers, the protective effect of moderate drinking still held up.

Neafsey and Collins suggest a third possible explanation: Small amounts of alcohol might, in effect, make brain cells more fit. Alcohol in moderate amounts stresses cells and thus toughens them up to cope with major stresses down the road that could cause dementia.

For people who drink responsibly and in moderation, there's probably no reason to quit. But because of the potential for alcohol to be abused, Neafsey and Collins do not recommend that abstainers begin drinking.

The researchers note that there are other things besides moderate drinking that can reduce the risk of dementia, including exercise, education and a Mediterranean diet high in fruits, vegetables, cereals, beans, nuts and seeds. Even gardening has been shown to reduce the risk of dementia.

Moreover, there are times when people should never drink, including adolescence, pregnancy and before driving, the researchers said.

Provided by Loyola University Health System

After a few drinks, older adults more impaired than they think

GAINESVILLE, Fla., 07 mar 2009— Older, active people who have a drink or two might be more impaired afterward than they think, according to a report today from a University of Florida research group in the Journal of Studies on Alcohol and Drugs.

Although people 50 or older in the study metabolized alcohol similar to how younger people did, they performed worse on special tests after having moderate amounts of alcohol and did not always realize when they were impaired. Soon after having alcohol, older adults also took on average five seconds longer to complete a test than their counterparts who did not have a drink.

"That doesn't sound like much, but five seconds is a big difference if you're in a car and need to apply the brakes," said lead author Sara Jo Nixon, Ph.D., a psychiatry professor at UF's McKnight Brain Institute. "It can mean the difference between a wreck, and not-a-wreck."

In 2007, an estimated 12,998 people were killed in crashes involving alcohol-impaired drivers, according to the National Highway Traffic Safety Administration.

"We still have a tremendous overhead in the United States of terrible tragedy with drinking and driving," said Edith Vioni Sullivan, Ph.D., a professor of psychiatry and behavioral sciences at the Stanford University School of Medicine. "We usually hear about the deaths; we seldom hear about the serious accidents that put people into nursing homes and hospitals for the rest of their lives."

More than half of adults older than 55 drink socially, according to a 2008 report from the Substance Abuse and Mental Health Services Administration. But few studies have focused on the short-term effects of social drinking among older adults. Previous research mainly investigated consumption of large amounts of alcohol at one time, and generally in young people. But results from studies of younger adults might not be applicable to older people because of age-related declines in cognitive skills, as well as changes in how alcohol is metabolized and removed from the body.

Nixon's group aimed to expand understanding of the effects over time of moderate levels of alcohol consumption in healthy, active older adults.

"You want to know how long does it take for them to become sober enough to engage in potentially dangerous activity such as driving," Sullivan said.

The study involved 68 nonsmokers — one group aged 50 to 74 and a comparison group aged 25 to 35 — who had at least one drink a month. Within each group, some individuals were given alcohol while others were given a placebo beverage that did not elevate their breath alcohol levels. The groups were carefully matched by gender, body mass index, history of alcohol consumption and other demographic characteristics.

When a person consumes alcohol, concentration in the blood builds to a peak, then dissipates. During the first phase of the metabolic process, alcohol has a stimulating effect. During the second phase, there is a sedative or depressive effect.

During each phase — at 25 minutes and 75 minutes after alcohol consumption, respectively — participants were given tests that required them to draw lines connecting numbered and lettered dots on a paper, in chronological order, without lifting the pen from the paper. They were timed and evaluated for how many errors they made. The first test involved numbers, while the second involved alternating between numbers and letters. Those tests give clues about a person's mental processing related to movement, and about the ability to mentally shift from one problem-solving strategy to another. The researchers also asked participants to rate on 10-point scales how intoxicated they felt, and how much they thought the alcohol impaired their performance.

Older adults who had alcohol took longer to complete the tasks than younger adults who had alcohol. But there was no such age difference between the older and younger groups that had not had alcohol. The researchers found that even though blood alcohol levels for participants in both groups rose at a similar rate right after drinking and reached the same peak, the older adults did worse on tests. That suggested the performance gap seen after moderate amounts of alcohol was not because of age-related differences in how the body processes the substance, but because of other factors influencing how alcohol affected the individuals.

In the test portion during the "stimulating" alcohol phase, older adults who had alcohol were slower than those who had not had any. In contrast, alcohol seemed to give the younger group a performance boost during that phase.

"People shouldn't take it to mean that younger people can drink with impunity," Sullivan said.

During that same post-drinking phase, when the older adults were impaired, they didn't think they were. And in the second phase — an hour and 15 minutes after having alcohol — older adults thought their performance was impaired, even when it wasn't.

"An older person might say 'Really, I feel all right, I'm sure I can drive,'" Sullivan said. "But the study shows that you can't always take someone at their word."

So what advice would Nixon give to active, older adults?

"If you have a couple of drinks at dinner, sit around, have dessert — don't drive for a while."

The researchers didn't evaluate the role of interactions between alcohol and prescription and other medicines.

They hope to conduct studies with larger numbers of people, more age groups and a wider range of alcohol intake levels. Future studies in which subjects take multiple, more difficult tests; the same individual is observed under different circumstances; and differences between the sexes are evaluated might shed more light on alcohol effects in older active adults.