C-Reactive Protein Linked to Cognition in Older Adults

Higher levels of hs-CRP associated with poorer executive function performance, MRI findings

30 mar 2010-- Low-grade inflammation, as measured by high-sensitivity C-reactive protein (hs-CRP), is associated with cerebral microstructural disintegration and poorer performance in executive function in older adults, according to research published in the March 30 issue of Neurology.

Heike Wersching, M.D., of the University of Münster in Germany, and colleagues analyzed data from 447 individuals (mean age, 63 years) who provided a blood sample and underwent neuropsychological assessment. All were stroke-free. Of these, 321 also underwent high-field magnetic resonance imaging.

After adjustment for a variety of factors, including age and cardiovascular risk factors, the researchers found that higher levels of hs-CRP were associated with poorer performance in executive function. Higher levels of hs-CRP were also associated with lower global fractional anisotropy and regional fractional anisotropy scores of the corpus callosum, frontal lobes, and corona radiata. However, hs-CRP was not linked to white matter hyperintensity or brain atrophy.

"Recent interventional studies using anti-inflammatory drugs such as aspirin and statins to lower circulating CRP levels showed a significant reduction in the incidence of cardiovascular events. There is also evidence of a beneficial effect of lifestyle interventions on cognitive functions, such as physical activity and body weight control, which have been shown to decrease circulating CRP levels. Whether lowering of CRP can also prevent cognitive decline and/or microstructural white matter alterations needs to be addressed in upcoming clinical trials," the authors conclude.

Several co-authors reported financial relationships with pharmaceutical companies and publications.

Abstract

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AHA/HBP: CRP Linked to BP, Metabolic Syndrome


Animal study suggests that CRP is associated with a wide range of adverse metabolic changes

27 sept 2009-- C-reactive protein (CRP) is not just a secondary marker of inflammatory disease but may be directly associated with hypertension and the metabolic syndrome, according to research presented this week at the American Heart Association's 63rd High Blood Pressure Research Conference, held from Sept. 23 to 26 in Chicago.

Michal Pravenec, M.D., of the Czech Academy of Sciences in Videnska, and colleagues studied spontaneously hypertensive rats with or without transgenically expressed human CRP in the liver under control of the apoE promoter.

Compared to control rats, the researchers found that treated rats showed hyperinsulinemia despite similar serum glucose levels, resistance to insulin stimulated non-oxidative glucose metabolism in skeletal muscle, elevated triglycerides, reduced serum adiponectin, and microalbuminuria. They also found evidence that treated rats had increased oxidative tissue damage.

"In addition, the results indicate that humanized CRP transgenic spontaneously hypertensive rats may provide a valuable model for 1) investigating mechanisms whereby human CRP enhances the risk for hypertension, diabetes, and target organ damage and 2) testing the therapeutic effects of new CRP inhibitors being developed for the prevention and treatment of common forms of cardiovascular and metabolic disease," the authors conclude.