Showing posts with label longevity. Show all posts
Showing posts with label longevity. Show all posts

Thursday, April 11, 2024

 

More schooling is linked to slowed aging and increased longevity

age
Credit: Pixabay/CC0 Public Domain

Participants in the Framingham Heart Study who achieved higher levels of education tended to age more slowly and went on to live longer lives as compared to those who did not achieve upward educational mobility, according to a new study at Columbia University Mailman School of Public Health and The Robert N. Butler Columbia Aging Center. Upward educational mobility was significantly associated with a slower pace of aging and lower risk of death. The results are published online in JAMA Network Open.

11 april 2024--The Framingham Heart Study is an ongoing observational study first initiated in 1948 that currently spans three generations.

The Columbia analysis is the first to connect educational mobility with pace of biological aging and mortality.

"We've known for a long time that people who have higher levels of education tend to live longer lives. But there are a bunch of challenges in figuring out how that happens and, critically, whether interventions to promote educational attainment will contribute to healthy longevity," said Daniel Belsky, Ph.D., associate professor of Epidemiology at Columbia Mailman School and the Aging Center and senior author of the paper.

To measure pace of aging, the researchers applied an algorithm known as the DunedinPACE epigenetic clock to genomic data collected by the Framingham Heart Study.

The latest findings showed that, according to the yardstick of the DunedinPACE epigenetic clock, two years of additional schooling translated to a 2–3% slower pace of aging. This slowing in the pace of aging corresponds to a roughly 10% reduction in risk of mortality in the Framingham Heart Study, according to previous research by Belsky on the association of DunedinPACE with risk of death.

DunedinPACE was developed by the Columbia researchers and colleagues and reported in January 2022. Based on an analysis of chemical tags on the DNA contained in white blood cells, or DNA methylation marks, DunedinPACE is named after the Dunedin Study birth cohort used to develop it.DunedinPACE (stands for Pace of Aging Computed from the Epigenome) is measured from a blood test and functions like a speedometer for the , measuring how fast or slow a person's body is changing as they grow older.

Biological aging refers to the accumulation of molecular changes that progressively undermine the integrity and resilience capacity of our cells, tissues and organs as we grow older.

The Columbia researchers used data from 14,106 Framingham Heart Study spanning three generations to link children's educational attainment data with that of their parents. They then used data from a subset of participants who provided blood samples during data collection to calculate the pace of biological aging using the DunedinPACE epigenetic clock.

In primary analysis, the researchers tested associations between educational mobility, aging, and mortality in a subset of 3,101 participants for whom educational mobility and pace of aging measures could be calculated.

For 2,437 participants with a sibling, the researchers also tested whether differences in educational attainment between siblings was associated with a difference in the pace of aging.

"A key confound in studies like these is that people with different levels of education tend to come from families with different educational backgrounds and different levels of other resources," explained Gloria Graf, a Ph.D. candidate in the Department of Epidemiology supervised by Belsky, and first author of the study.

"To address these confounds, we focused on educational mobility, how much more (or less) education a person completed relative to their parents, and sibling differences in educational attainment—how much more (or less) education a person completed relative to their siblings. These study designs control for differences between families and allow us to isolate the effects of education."

By combining these study designs with the new DunedinPACE epigenetic clock, the researchers were able to test how education affects the pace of aging. Then, by linking the education and pace of aging data with longitudinal records of how long participants lived, the team was able to determine if a slower pace of aging accounted for increased longevity in people with more education.

"Our findings support the hypothesis that interventions to promote educational attainment will slow the pace of biological aging and promote longevity," noted Graf.

"Ultimately, experimental evidence is needed to confirm our findings," added Belsky. "Epigenetic clocks like DunedinPace have potential to enhance such experimental studies by providing an outcome that can reflect impacts of education on healthy aging well before the onset of disease and disability in later life."

"We found that upward educational mobility was associated both with a slower pace of aging and decreased risk of death," said Graf.

"In fact, up to half of the educational gradient in mortality we observed was explained by healthier aging trajectories among better-educated participants." This pattern of association was similar across generations and held within family sibling comparisons: siblings with higher educational mobility tended to have a slower pace of aging as compared with their less educated siblings.

More information: Educational Mobility, Pace of Aging, and Lifespan Among Participants in the Framingham Heart Study, JAMA Network Open (2024). DOI: 10.1001/jamanetworkopen.2024.0655

Sunday, July 31, 2022

 

Biological age, not birthdate may reveal healthy longevity

age
Credit: Pixabay/CC0 Public Domain

A first-of-its-kind study of 1,813 older women suggests that the accelerated biological aging of the body—epigenetic age acceleration specifically—is associated with lower odds of living to be 90 years old and also being physically mobile and having intact mental function.

31 jul 2022--In the July 27, 2022 online edition of JAMA Network Open, a multi-institutional team of researchers led by the Herbert Wertheim School of Public Health and Human Longevity Science at University of California San Diego reported that epigenetic age acceleration could be used as a biomarker for healthy longevity and to estimate functional and cognitive aging.

"Older people know well that age is just a number that may not be indicative of their health status. What if we had a way to measure how fast we were aging that could predict our odds of living a long and healthy life? In aging research, we call this an individual's healthspan," said principal investigator Andrea LaCroix, Ph.D., M.P.H., Distinguished Professor at the Herbert Wertheim School of Public Health and Human Longevity Science.

Chronological age is based on a person's birthdate. Epigenetic age refers to the biological age of a person's cells, tissues and organ systems. If an individual's epigenetic age is greater than their chronological age, the person is undergoing epigenetic age acceleration, which is associated with higher risk of cancer, cardiovascular disease, Parkinson's disease and other diseases.

Based on four different epigenetic "clocks" that measure biological aging, every five to eight years of epigenetic age acceleration was associated with 20% to 32% lower odds of living to age 90 with intact mobility and cognitive function.

"Healthspan is important because the number of individuals who will live to be 90 years and older will quadruple from 1.9 million in 2016 to 7.6 million in 2050 in the United States alone," said LaCroix.

As part of the prospective study, the team analyzed data on physical and cognitive status from 1,813 women who participated in the Women's Health Initiative, a long-term national health study funded by the National Heart, Lung, and Blood Institute that began in 1993. The median age of death among Women's Health Initiative participants was 90 years.

Among this cohort, 464 women survived to the age of 90 with intact mobility and cognitive functioning, 420 lived to 90 but without intact mobility and cognitive functioning, and 929 women who died before reaching 90.

Study participants were 70 to 72 years old at baseline and were followed until at least age 90 or the time of their deaths. The associations of the epigenetic age acceleration clocks with healthy longevity were found to be independent of other characteristics more common among the long-lived women with intact mobility and memory compared to those who did not survive to age 90 including being white, having no or fewer chronic conditions at baseline, having higher education, not smoking and walking multiple times per week.

"Prior studies have shown that epigenetic age acceleration is associated with increased risk of death, and a few studies observed that slower age acceleration occurs among long-lived individuals. But this is the first study to prospectively examine the relationship between slower age acceleration and living to age 90 with preserved mobility and memory," said first author Purva Jain, Ph.D., who completed this work as part of her doctoral dissertation at UC San Diego.

Jain graduated from the epidemiology track of the Herbert Wertheim School of Public Health's Joint Doctoral Program in Public Health in December 2021.

"Furthermore, our study suggests we can use epigenetic age acceleration to estimate the risk of an individual not attaining healthy longevity, which could lead to future public health interventions to counteract poor health outcomes among older populations," said Jain.


More information: Purva Jain et al, Analysis of Epigenetic Age Acceleration and Healthy Longevity Among Older US Women, JAMA Network Open (2022). DOI: 10.1001/jamanetworkopen.2022.23285
Provided by University of California - San Diego 

Wednesday, September 02, 2020

 

Be generous, live longer

sharing
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The act of giving and receiving increases well-being: the recipient benefits directly from the gift, and the giver benefits indirectly through emotional satisfaction. A new study published in the journal PNAS now suggests that those who share more also live longer. In their analysis, Fanny Kluge and Tobias Vogt found a strong linear relationship between a society's generosity and the average life expectancy of its members. The researchers at the Max Planck Institute for Demographic Research in Rostock, Germany, conclude that people are living longer in societies whose members support each other with resources.

02 september 2020--"What is new about our study is that for the first time we have combined transfer payments from state and family and evaluated the effect", says Fanny Kluge. The researchers used data for 34 countries from the National Transfer Accounts project. For all countries, state and private transfer payments received and given by each individual over his or her lifetime are added up and presented in relation to lifetime income.

Societies in Western European countries share a lot and live long

Sub-Saharan African countries such as Senegal share the lowest percentage of their lifetime income and have the highest mortality rate of all the countries studied. Those who share little die earlier. Although South Africa is economically more developed than other African countries, few resources are redistributed; here too, the mortality rate is relatively high. In these countries, the mortality rate of children and young people up to the age of 20 is also higher than in the other countries studied. "Our analyses suggest that redistribution influences the mortality rate of a country, regardless of the per capita gross domestic product," says Fanny Kluge.

Societies in Western European countries and Japan transfer a lot to the youngest and oldest and mortality rates are low. The countries studied in South America also have high transfer payments. There, people share more than 60 percent of their average life income with others. The mortality rates are lower than in sub-Saharan Africa, but higher than those of Western Europe, Australia, Japan and Taiwan.

In France and Japan, the two countries with the lowest mortality rates of all the countries studied, an average citizen shares between 68 and 69 percent of their lifetime income. Here, the risk of dying in the coming year is only half as high for people over 65 as in China or Turkey, where between 44 and 48 percent of lifetime income is redistributed.

"What I find particularly interesting is that the relationship between generosity and lifetime income that we described does not depend on whether the benefits come from the state or from the wider family," says Fanny Kluge. Both of these factors cause the population live longer compared to societies with fewer transfer payments.


More information: Tobias Vogt et al, Intergenerational resource sharing and mortality in a global perspective, Proceedings of the National Academy of Sciences (2020). DOI: 10.1073/pnas.1920978117
Journal information: Proceedings of the National Academy of Sciences 

Provided by Max Planck Society 

Sunday, March 08, 2020

Men and women live longer in countries with higher gender parity

good life
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In advance of International Women's Day (Sunday, March 8), new research from the WORLD Policy Analysis Center at the UCLA Fielding School of Public Health (WORLD) shows that in countries where gender parity is high, both men and women live longer than in countries where equality is low.
08 mar 2020--Specifically, countries where educational gender parity is higher could expect years of greater life expectancy for both men and women, along with significantly fewer maternal deaths per 100,000 live births. A separate but related measure of women's participation in the labor force suggests that increased gender parity in the workplace is also associated with a lower national maternal mortality rate and significant extensions to female life expectancy.
 "This study marks an important step in quantitatively debunking the notion that women's improved social standing and access to secure livelihoods come at men's expense. Our research suggests that both men and women can gain from such shifts," said Dr. Jody Heymann, founding director of WORLD and a UCLA distinguished professor of public health, public policy and medicine. "Additionally, male life expectancy may potentially be extended through educational equality."
The study is scheduled for online publication March  in EClinicalMedicine, a medical journal published by The Lancet. Heymann and co-author, Dr. Adva Gadoth, a former Hilton Fellow at WORLD and current postdoctoral scholar at the UCLA Fielding School of Public Health, found the results held true in measures of both educational and work equality. These are defined as the overall proportion of girls or women participating in each area out of a total age-eligible population of females at the national level, and how that compares with those for boys or men in the same country.
A 10% increase in the authors' newly developed educational parity index – equivalent to a 4.9% increase in a country's gross annual school enrollment across primary and secondary schools and higher education – is associated with two years of greater female life expectancy, and almost a year greater male life expectancy at birth, even after accounting for individual countries' GDP, unemployment rates, urbanization, and domestic government health expenditures.
The same 10% increase in a country's educational parity was also associated with a reduction of almost 60 maternal deaths per 100,000 live births nationally. The educational parity index is defined as the average product of a country's female-to-male enrollment ratios and female enrollment rates across all levels of schooling.
Separately, a 10% increase, this time in female labor force participation, is associated with 15 fewer maternal deaths per 100,000 live births, and almost a full year's extension of female life expectancy at birth, with no effect on male life expectancy. The work parity index is defined as a given country's average female-to-male ratios of professional, technical, and managerial workers, and total female labor force participation.
The researchers said the work so far suggests that increases in gender equity can pay off beyond the realm of education and work.
"Improving gender equality through policy and other programmatic interventions is a win-win," Gadoth said. "Our research shows that increasing women's participation in society at large can have broad, positive impacts on population health in addition to reducing poverty, promoting human rights, and increasing people's personal agency around the globe."
More information: Gender parity at scale: Examining correlations of country-level female participation in education and work with measures of men's and women's survival. EClinicalMedicine. DOI:doi.org/10.1016/j.eclinm.2020.100299
Provided by University of California, Los Angeles

Thursday, January 09, 2020

Healthy habits in middle age linked to longer life free from disease

healthy lifestyle
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Sticking to a healthy lifestyle including not smoking, not being overweight, and exercising regularly, is associated with a longer life expectancy at age 50 free of major diseases such as cancer, cardiovascular diseases, and diabetes, finds a study in The BMJ today.
09 jan 2020--The number of extra disease-free years is around 7.6 for men and 10 for women, compared with participants with no low risk lifestyle factors.
Across the world people are, on average, living longer. But as populations age, individuals often live with disabilities and chronic diseases like cancer, heart disease, and diabetes.
Lifestyle factors such as smoking, physical activity, alcohol intake, body weight and diet quality affect both overall life expectancy and likelihood of chronic diseases, but few studies have looked at how a combination of lifestyle factors may relate to life expectancy free from such diseases.
To address this evidence gap, researchers analysed data on 73,196 US registered female nurses from the Nurses' Health Study and 38,366 US male health professionals from the Health Professionals Follow-up Study, who were free of cancer, cardiovascular disease, and diabetes at enrollment.
Five low risk lifestyle factors—never smoking, healthy weight (BMI), at least 30 minutes of daily physical activity, moderate alcohol intake, and a good quality diet—were used to calculate a healthy lifestyle score.
The sum of these five scores together gave a final low risk lifestyle score ranging from 0 to 5, with higher scores indicating a healthier lifestyle.
Participants were assessed regularly over a period of more than 20 years. During this time, new diagnoses and deaths from cancer, cardiovascular disease, and type 2 diabetes were recorded.
After adjusting for age, ethnicity, family medical history, and other potentially influential factors, life expectancy free of cancer, cardiovascular disease, and diabetes at age 50 was 24 years for women who adopted no low risk lifestyle factors, and 34 years for women who adopted four or five low risk factors.
Similarly, life expectancy free of any of these chronic diseases was 24 years among men who adopted no low risk lifestyle factors and 31 years in men who adopted four or five low risk lifestyle factors.
Women with four or five low risk lifestyle factors had 10.6 years' longer life expectancy free of the major chronic diseases than did women with zero low risk lifestyle factors, while men gained 7.6 years' longer life expectancy free of major chronic diseases over those with zero low risk lifestyle factors.
Men who smoked heavily (15 or more cigarettes a day) or obese men and women (body mass index of 30 or over) had the lowest proportion (75% or less) of disease-free life expectancy at age 50.
This is an observational study so can't establish cause, and the authors point to some limitations, such as relying on self reported lifestyle habits and participants being mainly white health professionals so results may not apply more generally.
Nevertheless, the data covered a large number of people with detailed and repeated assessment of lifestyle factors over a long follow-up period.
As such, they say: "Public policies for improving food and the physical environment conducive to adopting a healthy diet and lifestyle, as well as relevant policies and regulations (for example, smoking ban in public places or trans fat restrictions) are critical to improving life expectancy, especially life expectancy free of major chronic diseases."

More information: Healthy lifestyle and life expectancy free of cancer, cardiovascular disease, and type 2 diabetes: prospective cohort study, BMJ (2020). DOI: 10.1136/bmj.l6669 , https://www.bmj.com/content/368/bmj.l6669
Journal information: British Medical Journal (BMJ) 
Provided by British Medical Journal 

Friday, November 15, 2019

Report identifies three dimensions to lifelong 'longevity fitness'

old people
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Perseverance and attention to social connections, health, and finances will give people the best chance to thrive as they age, according to a new report titled "Longevity Fitness: Financial and Health Dimensions Across the Life Course." It also says that policymakers, employers, and individuals can take actions now to give people the best chance of maintaining their longevity fitness as older adults.
15 nov 2019--The publication was developed by The Gerontological Society of America (GSA) and supported by Bank of America. It uses the term longevity fitness to describe how people can thrive, not just survive, through social, health, and wealth equity.
It further sheds light on a growing body of literature showing that people can make the most of opportunities that come their way by taking three steps: cultivating social relationships with friends and close relatives, maintaining one's health through prevention and lifestyle, and building wealth by living within one's means and saving for the future.
"This report translates the science of so many GSA members and describes the many challenges and opportunities across the life course in maximizing our financial and health fitness," said Peter Lichtenberg, Ph.D., ABPP, FGSA, of Wayne State University, who chaired the advisory board that oversaw content development for the new publication.
Research and innovations addressing the three steps are examined through vignettes about four generations of a fictional family—Mary, Robert, Judy, and Bob—whose respective stories illustrate the challenges of thriving at 85, 65, 45, and 25 years of age. Mary's story of overlapping pressures that occur as people age into their 80s and 90s is presented first, followed by Robert's need for social ties as he retires, Judy as her children leave home and she focuses on the health challenges of midlife, and Bob as he ponders the financial aspects of life as a millennial.
"With this research, The Gerontological Society of America has taken an important step to better understand how to navigate our journeys in life in an era of longer life spans," said Lorna Sabbia, head of Retirement and Personal Wealth Solutions, Bank of America. "This study, together with our own research on life priorities and life stages, provides actionable guidance to individuals and families throughout their financial lives."

More information: "Longevity Fitness: Financial and Health Dimensions Across the Life Course."
Provided by The Gerontological Society of America

Sunday, October 13, 2019

Dog ownership associated with longer life, especially among heart attack and stroke survivors


dog
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Dog ownership may be associated with longer life and better cardiovascular outcomes, especially for heart attack and stroke survivors who live alone, according to a new study and a separate meta-analysis published in Circulation: Cardiovascular Quality and Outcomes, a journal of the American Heart Association.
13 oct 2019--"The findings in these two well-done studies and analyses build upon prior studies and the conclusions of the 2013 AHA Scientific Statement 'Pet Ownership and Cardiovascular Risk' that dog ownership is associated with reductions in factors that contribute to cardiac risk and to cardiovascular events," said Glenn N. Levine, M.D., chair of the writing group of the American Heart Association's scientific statement on pet ownership. "Further, these two studies provide good, quality data indicating dog ownership is associated with reduced cardiac and all-cause mortality. While these non-randomized studies cannot 'prove' that adopting or owning a dog directly leads to reduced mortality, these robust findings are certainly at least suggestive of this."
Given previous research demonstrating how social isolation and lack of physical activity can negatively impact patients, researchers in both the study and meta-analysis sought to determine how dog ownership affected health outcomes. Prior studies have shown that dog ownership alleviates social isolation, improves physical activity and even lowers blood pressure—leading researchers to believe dog owners could potentially have better cardiovascular outcomes compared to non-owners.
Dog ownership and survival after a major cardiovascular event—a registry-based, prospective study
Researchers in this study compared the health outcomes of dog owners and non-owners after a heart attack or stroke using health data provided by the Swedish National Patient Register. Patients studied were Swedish residents ages 40-85 who experienced heart attack or ischemic stroke from 2001-2012.
Compared to people who did not own a dog, researchers found that for dog owners:
  • The risk of death for heart attack patients living alone after hospitalization was 33% lower, and 15% lower for those living with a partner or child.
  • The risk of death for stroke patients living alone after hospitalization was 27% lower and 12% lower for those living with a partner or child.
In the study, nearly 182,000 people were recorded to have had a heart attack, with almost 6% being dog owners, and nearly 155,000 people were recorded to have had an ischemic stroke, with almost 5% being dog owners. Dog ownership was confirmed by data from the Swedish Board of Agriculture (registration of dog ownership has been mandatory since 2001) and the Swedish Kennel Club (all pedigree dogs have been registered since 1889).
The lower risk of death associated with dog ownership could be explained by an increase in physical activity and the decreased depression and loneliness, both of which have been connected to dog ownership in previous studies.
"We know that social isolation is a strong risk factor for worse health outcomes and premature death. Previous studies have indicated that dog owners experience less social isolation and have more interaction with other people," said Tove Fall, D. V. M., professor at Uppsala University in Sweden. "Furthermore, keeping a dog is a good motivation for physical activity, which is an important factor in rehabilitation and mental health."
While this study draws from a large sample, potential misclassifications of dog ownership in couples living together, death of a dog and change of ownership could have affected the outcomes of the study.
"The results of this study suggest positive effects of dog ownership for patients who have experienced a heart attack or stroke. However, more research is needed to confirm a causal relationship and giving recommendations about prescribing dogs for prevention. Moreover, from an animal welfare perspective, dogs should only be acquired by people who feel they have the capacity and knowledge to give the pet a good life."
Co-authors of the study are Mwenya Mubanga, M.D., M.P.H.; Liisa Byberg, Ph.D.; Agneta Egenvall, V.M.D., Ph.D.; Erik Ingelsson, MD, Ph.D. and Tove Fall, V.M.D., Ph.D. Agria Research Foundation and the Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS), grant number 2013-1673 funded the study.
Dog Ownership and Survival: A Systematic Review and Meta-Analysis
Researchers reviewed patient data of over 3.8 million people taken from 10 separate studies for a composite meta-analysis study. Of the 10 studies reviewed, nine included comparison of all-cause mortality outcomes for dog owners and non-owners, and four compared cardiovascular outcomes for dog owners and non-owners.
Researchers found that compared to non-owners, dog owners experienced a:
  • 24% reduced risk of all-cause mortality;
  • 65% reduced risk of mortality after heart attack; and
  • 31% reduced risk of mortality due to cardiovascular-related issues.
"Having a dog was associated with increased physical exercise, lower blood pressure levels and better cholesterol profile in previous reports," said Caroline Kramer, M.D. Ph.D., Assistant Professor of Medicine at the University of Toronto and an Endocrinologist and Clinician scientist at Leadership Sinai Centre for Diabetes at Mount Sinai Hospital, part of Sinai Health System. "As such, the findings that people who owned  lived longer and their risk for cardiovascular death was also lower are somewhat expected."
Studies deemed eligible for analysis included those conducted among adults age 18 or older, original data from an original prospective study, evaluated dog ownership at the beginning of the study and reported all-cause or cardiovascular mortality of patients. Studies were excluded if they were retrospective, did not provide an absolute number of events that occurred and reported non-fatal cardiovascular events.
"Our findings suggest that having a dog is associated with longer life. Our analyses did not account for confounders such as better fitness or an overall healthier lifestyle that could be associated with dog ownership. The results, however, were very positive," said Dr. Kramer. "The next step on this topic would be an interventional study to evaluate cardiovascular outcomes after adopting a dog and the social and psychological benefits of dog ownership. As a dog owner myself, I can say that adopting Romeo (the author's miniature Schnauzer) has increased my steps and physical activity each day, and he has filled my daily routine with joy and unconditional love."

More information: Circulation: Cardiovascular Quality and Outcomes (2019). DOI: 10.1161/CIRCOUTCOMES.118.005342
Journal information: Circulation: Cardiovascular Quality and Outcomes 
Provided by American Heart Association 

Monday, August 26, 2019

New evidence that optimists live longer


optimism
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Researchers from Boston University School of Medicine (BUSM), National Center for PTSD at VA Boston Healthcare System and Harvard T.H. Chan School of Public Health, have found that individuals with greater optimism are more likely to live longer and to achieve "exceptional longevity," that is, living to age 85 or older.
26 aug 2019--Optimism refers to a general expectation that good things will happen, or believing that the future will be favorable because we can control important outcomes. Whereas research has identified many risk factors that increase the likelihood of diseases and premature death, much less is known about positive psychosocial factors that can promote healthy aging.
The study was based on 69,744 women and 1,429 men. Both groups completed survey measures to assess their level of optimism, as well as their overall health and health habits such as diet, smoking and alcohol use. Women were followed for 10 years, while the men were followed for 30 years. When individuals were compared based on their initial levels of optimism, the researchers found that the most optimistic men and women demonstrated, on average, an 11 to 15 percent longer lifespan, and had 50-70 percent greater odds of reaching 85 years old compared to the least optimistic groups. The results were maintained after accounting for age, demographic factors such as educational attainment, chronic diseases, depression and also health behaviors, such as alcohol use, exercise, diet and primary care visits.
"While research has identified many risk factors for diseases and premature death, we know relatively less about positive psychosocial factors that can promote healthy aging," explained corresponding author Lewina Lee, Ph.D., clinical research psychologist at the National Center for PTSD at VA Boston and assistant professor of psychiatry at BUSM. "This study has strong public health relevance because it suggests that optimism is one such psychosocial asset that has the potential to extend the human lifespan. Interestingly, optimism may be modifiable using relatively simple techniques or therapies."
It is unclear how exactly optimism helps people attain longer life. "Other research suggests that more optimistic people may be able to regulate emotions and behavior as well as bounce back from stressors and difficulties more effectively," said senior author Laura Kubzansky, Ph.D., MPH, Lee Kum Kee Professor of Social and Behavioral Sciences and co-director, Lee Kum Sheung Center for Health and Happiness at the Harvard T.H. Chan School of Public Health. The researchers also consider that more optimistic people tend to have healthier habits, such as being more likely to engage in more exercise and less likely to smoke, which could extend lifespan. "Research on the reason why optimism matters so much remains to be done, but the link between optimism and health is becoming more evident," noted senior author Fran Grodstein, ScD, professor of epidemiology at the Harvard T.H. Chan School of Public Health and professor of medicine at the Channing Division of Network Medicine at Brigham and Women's Hospital and Harvard Medical School.
"Our study contributes to scientific knowledge on health assets that may protect against mortality risk and promote resilient aging. We hope that our findings will inspire further research on interventions to enhance positive health assets that may improve the public's health with aging," added Lee.
These findings appear in the journal Proceedings of the National Academy of Sciences.
More information: Lewina O. Lee el al., "Optimism is associated with exceptional longevity in 2 epidemiologic cohorts of men and women," PNAS (2019). www.pnas.org/cgi/doi/10.1073/pnas.1900712116
Journal information: Proceedings of the National Academy of Sciences 
Provided by Boston University School of Medicine 

Saturday, February 16, 2019

Your exercise performance is a better predictor of longevity than your chronological age

exercise
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Sophia Antipolis, 14 February 2019: It's often said: It's not how old you are, it's how old you feel. New research shows that physiological age is a better predictor of survival than chronological age. The study is published today in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology (ESC).
16 feb 2019--"Age is one of the most reliable risk factors for death: the older you are, the greater your risk of dying," said study author Dr. Serge Harb, cardiologist at the Cleveland Clinic in the United States. "But we found that physiological health is an even better predictor. If you want to live longer then exercise more. It should improve your health and your length of life."
Based on exercise stress testing performance, the researchers developed a formula to calculate how well people exercise—their "physiological age—which they call A-BEST (Age Based on Exercise Stress Testing). The equation uses exercise capacity, how the heart responds to exercise (chronotropic competence), and how the heart raterecovers after exercise.
"Knowing your physiological age is good motivation to increase your exercise performance, which could translate into improved survival," said Dr. Harb. "Telling a 45-year-old that their physiological age is 55 should be a wake-up call that they are losing years of life by being unfit. On the other hand, a 65-year-old with an A-BEST of 50 is likely to live longer than their peers."
The study included 126,356 patients referred to the Cleveland Clinic between 1991 and 2015 for their first exercise stress test, a common examination for diagnosing heart problems. It involves walking on a treadmill, which gets progressively more difficult. During the test, exercise capacity, heart rate response to exercise, and heart rate recovery are all routinely measured. The data were used to calculate A-BEST, taking into account gender and use of medications that affect heart rate.
The average age of study participants was 53.5 years and 59% were men. More than half of patients aged 50-60 years—55% of men and 57% of women—were physiologically younger according to A-BEST. After an average follow-up of 8.7 years, 9,929 (8%) participants had died. As expected, the individual components of A-BEST were each associated with mortality.
Patients who died were ten years older than those who survived. But A-BEST was a significantly better predictor of survival than chronological age, even after adjusting for sex, smoking, body mass index, statin use, diabetes, hypertension, coronary artery disease, and end-stage kidney disease. This was true for the overall cohort and for both men and women when they were analysed separately.
Dr. Harb said doctors could use A-BEST to report results of exercise testing to patients "Telling patients their estimated age based on  performance is a powerful estimate of longevity and easier to understand than providing results for the individual components of the examination."
Dr. Harb noted that this type of approach has shown merit in specific disease areas. For example, ESC guidelines advocate using "cardiovascular risk age—based on risk factors including smoking, blood cholesterol and blood pressure—to communicate with patients.

More information: Serge C Harb et al, Estimated age based on exercise stress testing performance outperforms chronological age in predicting mortality, European Journal of Preventive Cardiology(2019). DOI: 10.1177/2047487319826400
Massimo F. Piepoli et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice, European Heart Journal (2016). DOI: 10.1093/eurheartj/ehw106
Provided by European Society of Cardiology

Sunday, November 25, 2018

Building Bridges Across the Generational Divide
Despite all the hand-wringing about the graying of America, the needs and assets of older and younger people are complementary. The key is to overcome our habits of age segregation.
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By Marc Freedman
25 nov 2018--It’s meant as a joke—and a provocation. In an edgy new get-out-the-vote ad aimed at young people, a half dozen senior citizens taunt the younger generation, calling themselves a “generation of doers” not “whiners.” “Everything’s fine the way it is,” says one of the seniors, as another chimes in, “Climate change? That’s a you problem. I’ll be dead soon.”
The ad recalls Groucho Marx’s famous quip about posterity: “Why should I care about posterity? What’s posterity ever done for me?” And it reinforces the too-common view of America’s older population as greedy geezers out for themselves, hogging a disproportionate share of society’s resources—a dyspeptic demographic foreshadowing the country’s gray dawn.
This much is true: We are careening toward a future with a lot more older people, and for a country that’s always thought of itself as young, it comes as a shock to the system. Next year, for the first time ever, there will be more Americans over 60 than under 18, a shift that will become even more pronounced in the coming decades. With that transformation to a more-old-than-young society comes the seeming prospect of scarcity, conflict and isolation. Many see a looming zero-sum fight between “kids and canes,” competing for diminishing resources in a society split along generational lines.
Without discounting these challenges, I believe there is reason for optimism and the possibility of a far better outcome—one that could help us to avoid conflict and solve problems such as child care and loneliness, while also generating a good deal of personal happiness along the way. The route to this more uplifting prospect is neither obscure nor abstract. It’s right in front of us, if we shift the lens from fiscal woes to emotional truths. The fact is, for all the hand-wringing about the graying of America, the needs and assets of the generations fit together like pieces of a jigsaw puzzle. Just ask any grandparent.
‘The two loneliest groups in the country, according to a 2018 survey, are younger people and older people, in that order.’
There is significant evidence from evolutionary anthropology and developmental psychology that old and young are built for each other. The old, as they move into the latter phases of life, are driven by a deep desire to be needed by the next generation and to nurture it; the young have a need to be nurtured. It’s a complementary relationship that goes back to the beginning of human history.
For many decades, anthropologists tried to understand why women typically lived so long beyond reproductive age. Men could continue reproducing late in life. But from a narrow evolutionary standpoint, postmenopausal women seemed superfluous—until a quarter-century ago, when anthropologist Kristen Hawkes of the University of Utah advanced the “grandmother hypothesis.’’ Based on her research studying hunter-gatherer tribes, Dr. Hawkes found that older women played a critical role gathering food and caring for their daughters’ children, thus enabling the longer gestational period that separates humans from most other species. If not for them, we likely wouldn’t have evolved in the way we did or ended up having such long life spans.
Alison Gopnik, a psychologist and philosopher at the University of California, Berkeley—and a regular contributor to these pages—believes that the evolutionary role of grandmothers in caring for children “may actually be the key to human nature.” Such support, she writes, allows for longer childhoods and more time to “grow large brains and to use those brains to learn about the world we live in.”
ImageAt Gorham House in Portland, Maine, a senior residence shares a site with a preschool. Youngsters visit the senior center’s living room to play with the residents, called “Grand Friends,” as seen here last week. Residents also visit the classroom to join in activities. PHOTO: JASON GROW FOR THE WALL STREET JOURNAL 

The Stanford psychologist Laura Carstensen, a leading scholar of longevity, comes to similar conclusions, arguing that older people are essential to younger ones and to the well-being of the whole species. As Prof. Carstensen sees it, elders are a potential “cavalry coming over the hill” for the next generation. They tend to feel a growing need for meaningful relationships as they realize that fewer days are ahead of them than behind. They have a deeply rooted instinct to connect in ways that flow down the generational chain. And they possess the virtues of age—patience, persistence and emotional regulation, among others—which are especially helpful in dealing with young people.
But what does all this mean for us today, when foraging for roots and herbs for grandchildren may not be the best use of elders’ time? How can we tap the vast and largely underused talent of the older population to support the next generation, not only within families but across the broader community? How might we adapt the grandmother hypothesis to modern family life?
Despite the powerful fit between the needs of older and younger people, such connections don’t develop easily today because we’ve done so much to thwart them. Over the past century we have undertaken a radical social experiment, transforming American society from one of the most age-integrated in the world to what is, arguably, the most age-segregated.
Historians report that, in the 19th century, there was little consciousness of chronological age in the U.S. Individuals rarely knew their own age or the age of others. Most Americans lived in multigenerational households, working a farmstead together. One-room schoolhouses might include students in their 20s and 30s, sometimes older. In his 1992 book “How Old Are You?,” the Brown University cultural historian Howard Chudacoff explained that America’s “institutions were not structured according to age-defined divisions, and its cultural norms did not strongly prescribe age-related behavior.”
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Then industrialization and the assembly-line mentality intervened. Universal schooling gave rise to age-segregated institutions for primary and secondary education. Mandatory retirement and new policies such as Social Security—which set 65 as the definition of old age—accelerated the movement of older people out of the workplace. New institutions like nursing homes and senior centers, for all their advantages, further reinforced the new reality.
By the late 1940s, with lifespans lengthening, many older people felt excluded from much of American life and experienced a lack of purpose. UAW President Walter Reuther described retirees as “too old to work, too young to die.”
The market soon responded by inventing the retirement community, devoted to giving new direction to these “golden years.” The real-estate developer Del Webb, one-time owner of the New York Yankees, opened Sun City, the first large-scale retirement community, in the Arizona desert in 1960. It held out the promise of graying-as-playing, free from the noisy intrusions of the younger generation. On its opening weekend, 100,000 people flocked to the new town, producing the largest traffic jam in state history.
‘Intergenerational proximity has often brought with it not just support but a flowering of relationships.’
All of these developments have contributed to the unhappy situation that we face today: Young and old rarely encounter each other, ageism is on the rise, and public budgets are increasingly a battleground between clashing generational interests. Most telling perhaps is the fact that the two loneliest groups in the country are younger people and older people, in that order, according to a 2018 survey based on the UCLA Loneliness Scale and conducted by Ipsos for the health insurer Cigna.
Turning things around won’t happen simply or automatically, but there are emerging signs of hope and resilience. Innovators and entrepreneurs across the globe are working to reimagine modern daily life so that connections across generations happen more naturally and frequently.
Singapore offers a dramatic example. The city-state has launched a multibillion-dollar effort to create a “kampong for all ages,” embracing the Malay word for village in an effort to build “a cohesive society with intergenerational harmony.” To bring the generations together, officials are launching initiatives to have preschools share facilities with senior centers, recruit young people to teach technology to older people, and help organizations better use older volunteers. Since 2013 they’ve been building and promoting “3Gen flats,” designed for families to house grandparents and grandchildren under one roof. They’re also spending about $150 million to underwrite an innovation challenge to seek new ideas and research that promote productive aging.
If Singapore represents a grand plan, in the U.K. there’s the example of a charismatic Pied Piper. Two years ago, Financial Times columnist Lucy Kellaway, then 57, co-founded a group called Now Teach and then announced that she was leaving her job to become one of its recruits. She began training to become a math teacher in a low-income London school.
ImageRainbow Intergenerational Learning Center evolved from Miami seniors bringing their grandchildren to a Little Havana senior center. Now, seniors trained in early childhood education staff a Miami Beach location, where Emma Allen worked with preschooler Helena Nikolopoulos last week. PHOTO: SCOTT MCINTYRE FOR THE WALL STREET JOURNAL 
Ms. Kellaway challenged her readers over 50 to quit their jobs and join her. “Of the 35,000 who started teacher training in the U.K. last year, almost none of them—a mere 100—were over 55,” she wrote last year. “We were sure there were lots of fiftysomethings who wanted to teach.” In response to this challenge, a thousand older people applied for 47 slots, highlighting the longing of many older people to invest in the development of the next generation. Most, though not all, started as certified teachers this fall. Now Teach expanded beyond London this year and is training 80 new recruits. It has inspired other U.K. groups to try to develop new ways to tap older talent.
In the U.S., a number of entrepreneurs have been working for decades to bring the generations together, but only recently have they begun to find a small measure of philanthropic and government support.
In 2017, I visited Gorham House, a retirement and assisted living facility outside Portland, Maine, which was built around a preschool back in 1990. It turns out that the most coveted rooms for retirees are the ones nearest the children’s playground. The facility’s website proclaims to parents that Gorham’s early childhood program has a competitive advantage over other options: a built-in community of surrogate grandparents, whom Gorham calls “Grand Friends.” In Miami, a similar combination of activities evolved from a senior center to which grandparents often brought their grandchildren; it has become the home of Rainbow Intergenerational Child Care.
There are now more than 100 such “shared sites” in the U.S., pairing youths and elders for joint activities, according to a report published this year by the nonprofit group Generations United and the Eisner Foundation. An initiative launched at Ohio State in 2015, for instance, involves the university’s students in operating a program in Columbus that brings together preschoolers and seniors.
Higher education, long a bastion of age segregation, is also getting more direct intergenerational attention. Harvard, Stanford and the University of Minnesota have begun programs in the last decade aimed at helping people over 50 change careers or find fresh uses for their experiences in retirement. The older students take most classes alongside their younger counterparts, bringing real-life perspective to class discussions. Harvard calls it a “third stage of education.”
Other intergenerational efforts are aimed at promoting social and economic connections between young and old. In 2016, two recent graduates of the Massachusetts Institute of Technology began operating Nesterly, a start-up pairing older people who had room to spare in their homes with university students in need of reduced rent and able to do chores. The program, so far active just in Boston, is part of a pilot with the city’s government to provide affordable housing, help local homeowners and increase community stability. Last year in southern Oregon, Grandmas2Go launched with an initial cadre of 20 “Grandmas”—older people trained as coaches to help support struggling new parents and their babies. The program is in the process of going statewide.
Intergenerational proximity has often brought with it not just support but a flowering of relationships. In Cleveland, a senior living community called Judson Manor created an artist-in-residence program in 2010 providing free housing for graduate music students, who agree to perform for the residents and participate in meals and other activities. When one young violist living at Judson became engaged in 2014, she asked her 90-something neighbor to be part of the wedding party.
The reach of these various early efforts is modest, especially in relation to the scale of the social shift we’re facing. They underscore, however, the need to rethink how to live later life in ways that go with the grain of human development. Rather than trying so hard to be young, to cling to our faded youth, we need to be there for those who actually are young. To achieve this, we must be as creative at inventing institutions that bring Americans together as we have been over the past century in crafting ones that split us apart. Why not start our own equivalent of Singapore’s innovation challenge?
Making the most of the multigenerational world that’s already upon us is one of the surest routes to happiness in our longer lives. The psychiatrist George Vaillant, who led the landmark Harvard Study of Adult Development, tracking hundreds of men for decades, found that those in middle age or older who invest in nurturing the next generation are three times as likely to be happy as those who fail to do so. As he put it, “biology flows downhill.”
Of all the things that divide us, the gap between old and young is arguably the most bridgeable. Connecting across generations is not only pragmatic, it’s an essential part of the human experience and a key to the cycle of life. After all, the young will soon be the old—likely faster than they ever imagined.
—This essay is adapted from Mr. Freedman’s new book, “How to Live Forever: The Enduring Power of Connecting the Generations,” which will be published by Public Affairs on Nov. 20. He is the CEO and president of Encore.org.