Two NSAIDs Found Ineffective in Preventing Alzheimer Disease

According to a randomized, placebo-controlled study of naproxen and celecoxib published online in Neurology, NSAIDs don't prevent Alzheimer disease (AD).
Researchers tested this hypothesis, based on pathological evidence that points to an inflammatory component in AD, in over 2500 elderly volunteers with a family history of the disease. After 2 years, the risk for AD was insignificantly higher in each NSAID group compared with placebo users.
The authors write that their results suggest, "if anything, the reverse" of their hypothesis, but add that the findings "are too limited to be considered evidence that persons at risk for AD should avoid these or other NSAIDs when used for their approved indications."
BMJ reported last week that aspirin had no effect on cognitive decline in women.