Sunday, August 23, 2020

Surgical innovation promises better dialysis outcomes

Surgical innovation promises better dialysis outcomes
An illustration comparing the traditional approach to creating an arteriovenous fistulae in the arm to the scientists’ RADAR method. Credit: H. Bai et al., Science Translational Medicine (2020)

A new technique developed by a Yale-led research team improves blood flow in surgically made blood vessels used in dialysis, enables them to last longer, and results in fewer complications than the standard technique.

23 august 2020--The findings, based on work with hundreds of patients and supported by animal studies, appear in the Aug. 19 issue of Science Translational Medicine

Of more than 661,000 Americans with kidney failure, according to the National Institute of Diabetes and Digestive and Kidney Diseases, 468,000 are on dialysis, a method of filtering waste from the blood when the kidneys are damaged or fail. But the standard way of accessing a patient's blood flow has shortcomings the new technique overcomes.

Typically, vascular surgeons fashion a vein-to-artery arteriovenous fistula (AVF)—a larger, stronger blood vessel—by dividing a vein in the patient's wrist and joining it to the artery. This enhances blood flow and vein access for the two needles that route a patient's blood through the dialysis machine and back into the body. 

Yet the method, standard procedure for the last 50 years, has "the worst results of any procedure we do," said Yale School of Medicine's Dr. Alan Dardik, professor of surgery (vascular) and of cellular and molecular physiology, and senior author of the study.

Sixty percent of fistulas fail to mature, and only 50% are still usable a year later. For women, success rates are even lower, with just 40% of fistulas still usable at one year. 

Surgical innovation promises better dialysis outcomes
Shear stress on vessels (colored regions) was lower in key spots in the new RADAR configuration (bottom row) than in the conventional vein-to-artery configuration (top row) in male rats. Credit: H. Bai et al., Science Translational Medicine (2020)

For the many cases in which the fistula can't be maintained, Dardik said, patients need an artificial graft, which has an even lower success rate.

"Eventually these patients can only receive dialysis with a catheter," he said, a procedure that carries increased risk of infection and death. Patients receiving dialysis by catheter have a 1.6 to 2.5 times higher mortality rate than those receiving dialysis by fistulas.

In the new surgical technique, known as radial artery deviation and reimplantation, or RADAR, surgeons essentially reverse the procedure, bringing the artery over to the vein. They also use a tourniquet instead of clamps to temporarily stop blood flow while operating. This requires less handling of the artery and vein than the traditional method and results in better blood flow and a more robust fistula.

"It works a heck of a lot better," said Dardik. 

Building on a 2016 pilot study of RADAR's effectiveness involving 53 patients, the new study examined 201 patients who had the novel artery-to-vein surgery and compared them with 73 who had the traditional vein-to-artery surgery.

At one year, 72.2% of the RADAR patients had viable fistulas, compared with 48.1% of traditional fistula patients. At three years, fistulas remained viable in 62.1% of RADAR patients versus 37.6% of patients with traditional fistulas.

Notably, the new procedure was just as successful for female patients as male patients. 

The researchers confirmed their findings in animal (rat) studies in which they created both artery-to-vein fistulas and vein-to-artery fistulas, and examined the differences. The results closely mirrored those for the human patients.

The animal studies also made clear why the new technique was more effective. Using CAT scans and ultrasound, researchers observed crucial differences in hemodynamics between the two surgical techniques. "The pattern of blood flow in the RADAR technique was better than the usual pattern of flow with the conventional technique," Dardik said.

Given the significant need for dialysis, Dardik said, the new technique offers a clear opportunity for improving patient outcomes through more robust fistulas and fewer procedures to maintain access and the related complications.

"Surgeons always want the best for their patients," he said, "and the RADAR procedure lets surgeons do their best."


More information: Hualong Bai et al. Artery to vein configuration of arteriovenous fistula improves hemodynamics to increase maturation and patency, Science Translational Medicine (2020). DOI: 10.1126/scitranslmed.aax7613
Journal information: Science Translational Medicine 

Provided by Yale University 

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