Thursday, May 08, 2014

Perceived age and weight discrimination worse for health than perceived racism and sexism

Perceived age and weight discrimination, more than perceived race and sex discrimination, are linked to worse health in older adults, according to new research from the Florida State University College of Medicine.
The findings are part of a study measuring changes in health over a four-year period and published in the American Journal of Geriatric Psychiatry.
08 may 2014--"Our previous research showed that perceived discrimination based on body weight was associated with risk of obesity. We wanted to see whether this association extended to other health indicators and types of discrimination," said lead author Angelina Sutin, assistant professor of behavioral sciences and social medicine.
"What we found was unexpected and striking."
Sutin and colleagues found that older adults who perceived weight discrimination and older adults who perceived discrimination based on age, a physical disability or other aspect of appearance had significantly lower physical and emotional health and greater declines in health compared to people who did not report experiencing such discrimination.
In contrast, perceived discrimination based on relatively fixed characteristics—race, sex, ancestry and sexual orientation—were largely unrelated to declines in physical and emotional health for the older adults.
The findings are based on a sample of more than 6,000 adults who participated in the Health and Retirement Study, a study of Americans ages 50 and older and their spouses. Participants reported on their physical, emotional and cognitive health in 2006 and 2010 and also reported on their perceived experiences with discrimination.
"We know how harmful discrimination based race and sex can be, so we were surprised that perceived discrimination based on more malleable characteristics like age and weight had a more pervasive effect on health than discrimination based on these more fixed characteristics," Sutin said.
The one exception was loneliness.
Loneliness was the most widespread health consequence of discrimination among older adults. Discrimination based on every characteristic assessed in Sutin's study was associated with greater feelings of loneliness. According to previous studies, the effects of chronic loneliness are severe: increased risk for unhealthy behaviors, sleep disturbances, cardiovascular risk factors and suicide.
"Humans have a strong need to belong, and people often feel distressed when they do not have their desired social relationships," Sutin said. "Our research suggests that perceiving a hostile society is associated with pervasive feelings of loneliness. An individual may interpret discrimination as an indication that they do not fit in the society in which they live."
Provided by Florida State University

Wednesday, May 07, 2014

Largest ever analysis on the use of a polypill in cardiovascular disease

New data presented for the first time at the World Heart Federation's World Congress of Cardiology 2014 shows a significant improvement in both patient adherence and risk factor control when patients at high risk of heart attack or stroke receive a polypill, compared to usual care. A polypill is a fixed dose combination of commonly-used blood pressure and cholesterol lowering medications, along with aspirin, which helps prevent cardiovascular disease (CVD).
07 may 2014--The Single Pill to Avert Cardiovascular Events (SPACE) project, led by researchers from The George Institute for Global Health, analysed data from 3140 patients with established CVD or at high risk of CVD in Europe, India and Australasia. The results showed a 43 per cent increase in patient adherence to medication at 12 months with the polypill, in addition to corresponding improvements in systolic blood pressure and LDL-cholesterol that were highly statistically significant. The largest benefits were seen among patients not receiving all recommended medications at baseline, which corresponds to mostcardiovascular disease patients globally.
"These results are an important step forward in the polypill journey and management of cardiovascular disease", commented Ruth Webster of the George Institute for Global Health, Sydney. "Most patients globally either don't start or don't continue taking all the medications they need, which can lead to untimely death or further CVD events. An important finding from our analyses is that the greatest benefits from a polypill were for currently untreated individuals. Although the idea of a polypill has always been appealing, we now have the most comprehensive real-world analysis to date of this treatment strategy in high risk CVD patients. Given the potential affordability, even in low income countries, there is considerable potential to improve global health."
CVD is the number one cause of death globally, killing 17.3 million people each year and it is expected to remain the world's leading cause of death in the near future. Access to effective treatment like polypills can play a key part in achieving the bold World Health Organization (WHO) target of at least a 25 per cent reduction in premature mortality from NCDs by 2025, especially as a polypill can be cheaper than several individual drugs.
Professor Salim Yusuf, President-elect of the World Heart Federation said: "These results emphasize the importance of the polypill as a foundation for a global strategy on cardiovascular disease prevention. It will improve patient access to essential medications at an affordable cost and wide use of the polypill can avoid several millions of premature CVD events. The polypill is however not a replacement for a healthy lifestyle and should be combined with tobacco avoidance, a healthy diet and enhanced physical activity. This broad strategy, if adopted widely, can reduce cardiovascular disease to a large extent."
SPACE combined results from three clinical studies which took place from 2009 – 2013: UMPIRE (Europe and India), Kanyini-GAP (Australia) and IMPACT (New Zealand). Importantly, in the Australasian trials, half the patients were indigenous. Further analysis of this unique data source is underway to investigate the effect of the polypill on major patient groups and the results of this are expected over the coming year.
Provided by World Heart Federation

Tuesday, May 06, 2014

New MRSA superbug emerges in Brazil

New MRSA superbug emerges in Brazil
This shows UTHealth researchers reporting on a superbug in Brazil are (from left to right) Barbara E. Murray, M.D.; Truc T. Tran, Pham.D; Jose M. Munita, M.D.; Diana Panesso, Ph.D; and Cesar Arias, M.D., Ph.D. Credit: The University of Texas Health Science Center at Houston (UTHealth)
An international research team led by Cesar A. Arias, M.D., Ph.D., at The University of Texas Health Science Center at Houston (UTHealth) has identified a new superbug that caused a bloodstream infection in a Brazilian patient. The report appeared in the April 17 issue of The New England Journal of Medicine.
05may 2014--The new superbug is part of a class of highly-resistant bacteria known as methicillin-resistant Staphylococcus aureus or MRSA, which is a major cause of hospital and community-associated infections. The superbug has also acquired high levels of resistance to vancomycin, the most common and least expensive antibiotic used to treat severe MRSA infections worldwide.
Most worrisome is that genomic analyses indicated that this novel vancomycin-resistant MRSA superbug belongs to a genetic lineage that is commonly found outside hospitals (designated community-associated MRSA), said Arias, the report's senior author and an associate professor of medicine, microbiology and molecular genetics at the UTHealth Medical School.
Previous research has suggested that community-associated MRSA can disseminate rapidly among people and is responsible for the majority of skin and soft tissue infections (sores) in patients of all ages. Some of these infections can become serious and even fatal.
Since community-associated MRSA is thought to be transmitted mainly by skin contact, the new superbug may affect not only sick people or those with a weakened immune system but also healthy individuals, according to Arias. Apart from causing localized skin infections, the MRSA superbug has the ability to invade the bloodstream and may become a serious threat.
"This is the first-ever reported bloodstream infection caused by a highly vancomycin-resistant MRSA bacteria," Arias said. "If we lose vancomycin, it would make it very difficult and expensive to treat these infections," he said.
Arias and his colleagues conducted microbiological and genetic analyses of an MRSA superbug recovered from the blood of a 35-year-old Brazilian man and identified a novel transferable genetic element (plasmid) that carries the genes necessary for vancomycin resistance (vanA gene cluster).
"The presence and dissemination of community-associated MRSA containing vanA could become a serious public health concern," report the authors in the paper.
However, since this is the only documented case of this type of infection, Arias said, it is too early to tell if this specific superbug will lead to a bigger threat.
Barbara E. Murray, M.D., report co-author and director of the Division of Infectious Diseases at the UTHealth Medical School, said, "The worst resistance possible has now appeared in the community-associated MRSA clone."
What is the next step?
"There will have to be increased surveillance in South America and worldwide in the future," said Murray, who is the holder of the J. Ralph Meadows Professorship in Internal Medicine at the UTHealth Medical School and president of the Infectious Diseases Society of America.
Provided by University of Texas Health Science Center at Houston

Monday, May 05, 2014

Evidence points to potential benefits of polypill for heart health

pills
Taking one pill instead of three could be a powerful ally to prevent cardiovascular disease, according to a new Cochrane systematic review of the latest research on polypills from a team of scientists at the London School of Hygiene & Tropical Medicine, Warwick Medical School and Northwestern Medicine.
05 may 2014--A polypill typically combines an aspirin, statin and at least one blood pressure medication into a single pill. The idea of putting multiple drugs into a single pill is not new; it is done in HIV combination therapy, for example. However, polypills have the potential for widespread use and could potentially help prevent heart attacks and stroke while helping people live longer. Such drug combinations are not yet on the market in the U.S. or the UK but can be bought online.
The review included analysis of 7,047 patients in nine randomized controlled trials from around the world from 2009 to 2013 and is the largest and most comprehensive review of polypill literature to date. The findings were published April 16 in the Cochrane Database of Systematic Reviews.
Scientists found that the combination therapy—taking one pill instead of three separate pills—made it easier for people to adhere to a treatment plan. In one large study, polypills were shown to improve adherence by 33 percent compared with those who underwent usual care for cardiovascular disease prevention, the scientists said.
In several of the latest studies, the scientists found that a polypill lowered systolic blood pressure and total cholesterol but the overall effects of a polypill may be similar to usual care. Adverse events were more common in people treated with a polypill but there was no strong evidence of a difference in serious adverse events between those taking a polypill and those on placebo or control.
"We know that half of the people around the world who have had a heart attack or stroke take zero medicines after the incident," said Mark Huffman, M.D., corresponding author of the review. "A single polypill could not only make it easier for patients to take their medications, but could also provide the maximal benefit from a single pill. However, there is not going to be one magical  for everybody. I think we can expect different polypills with different doses of medication."
Huffman is an assistant professor in preventive medicine and medicine-cardiology at Northwestern University Feinberg School of Medicine and a cardiologist at Northwestern Memorial Hospital. He is also the coordinating editor of the Cochrane Heart Group Satellite United States, which is based at the Feinberg School.
"Cardiovascular diseases, including heart attacks and strokes, are the leading cause of death and disability worldwide," said Shah Ebrahim, study co-author and professor of public health at the London School of Hygiene & Tropical Medicine. "In the Britain, they cause about a third of all deaths—more than 180,000 each year. Lowering blood pressure and cholesterol levels by introduction of a polypill could simplify treatment, improve adherence and thereby save lives and reduce health care costs."
Huffman said the polypill has the potential to be added to the World Health Organization's "Model List of Essential Medicines" in the future, maybe as soon as next year.
"The WHO has already named the polypill one of the 'top five best buys' for preventing chronic diseases globally, and while more research is needed, the polypill has the potential to avoid millions of premature deaths and related morbidity from cardiovascular disease at low cost," he said.
More information: "Fixed-dose combination therapy for the prevention of cardiovascular disease." Authors include: de Cates AN, Farr MRB, Wright N, Jarvis MC, Rees K, Ebrahim S, Huffman MD. Cochrane Database of Systematic Reviews2014, Issue 4. Art. No.: CD009868. DOI: 10.1002/14651858.CD009868.pub2.
Provided by Northwestern University

Monday, April 28, 2014

Vitamin D supplements have little effect on risk of falls in older people


Vitamin D

A new meta-analysis, published in The Lancet Diabetes & Endocrinology journal, concludes that there is no evidence to suggest that vitamin D supplements prevent falls, and that ongoing trials to test this theory are unlikely to change this result.
28 april 2014--The study, by Dr Mark Bolland of the University of Auckland, New Zealand, and colleagues, analysed findings from 20 randomised controlled trials which tested the potential of vitamin D supplements to reduce falls, in a total of 29535 people. The findings show that supplements do not reduce falls by 15% or more, meaning that the amount that vitamin D supplementation reduces fall risk at a population level is very low.
Falls can be devastating for older people, and strategies to reduce fall risk are urgently needed as the global population ages. The results of trials that have investigated the ability of vitamin D to prevent falls—and those of previous meta-analyses—have been mixed. It is unclear how vitamin D supplements might prevent falls but, until now, there has been enough positive evidence to support its recommendation by some health organisations.
Bolland and colleagues' findings add to those of previous meta-analyses by also applying trial sequential analysis, which predicts the potential of future trials with a similar design to sway existing evidence. Their results suggest that trials in progress are unlikely to overturn the finding that vitamin D supplements do not appreciably reduce falls, and they conclude that there is insufficient evidence to support prescribing vitamin D to reduce falls.
However, the authors report that existing evidence does not show whether vitamin D might reduce falls in particularly vulnerable older people—ie, those who fall often. This is because most clinical  report only the total number of falls in the study population, rather than the number of falls per person in the study.
According to Clifford Rosen of Maine Medical Research Institute, Scarborough, USA, and Christine Taylor of the National Institutes of Health, Bethesda, USA, both authors of a Comment linked to the study, "Whether a large trial is feasible in this vulnerable population remains to be established. Until then, we are left with uncertainty about the benefits of  D supplementation for reduction in fall risk, particularly among vulnerable older people."
Provided by Lancet

Wednesday, April 23, 2014

Brasil vive 'revolução da longevidade', diz médico Alexandre Kalache

A sociedade brasileira passa pela revolução da longevidade, afirmou o médico e presidente do Centro Internacional de Longevidade, Alexandre Kalache, nesta quinta-feira (27), durante o Fórum a Saúde do Brasil, realizado pela Folha em São Paulo.
Kalache citou dados sobre a evolução, nas últimas décadas, e as estimativas para o futuro da taxa de fecundidade e da expectativa de vida ao nascer.

Hoje as brasileiras têm uma média de 1,74 filhos ao longo da vida, enquanto na década de 1970 a taxa era de 5,8 filhos.
Os brasileiros também estão vivendo mais. Em 1970, a esperança de vida era de 53,5 anos e hoje ultrapassa os 75.

"Daqui a três décadas, nós seremos um país tão envelhecido quanto Japão é hoje", comparou Kalache. "Essa longevidade é uma dádiva, mas traz desafios importantes".
O médico destaca que, nos países desenvolvidos, onde a revolução já ocorreu, houve enriquecimento antes do envelhecimento. Já no Brasil, a população está envelhecendo em condições de pobreza, o que transforma a velhice em fardo.
Para Kalache, é importante executar políticas públicas que garantam a qualidade de vida dos idosos nesses anos de vida que eles ganharam. "Cada vez mais as mortes de pessoas com mais de 60 anos são decorrentes de doenças crônicas, como hipertensão e diabetes, que incapacitam e tiram a qualidade de vida da pessoa", afirma.
Segundo dado citado pelo médico, a proporção de mortes de pessoas acima de 60 anos corresponde a 67% do total. O desafio é investir na saúde dos idosos, já que, nessa faixa de idade ela requisita mais recursos. Ele disse que "o grande gasto com saúde geralmente está no último ano de vida".
Contudo, os gastos previstos pelo governo federal com a saúde do idoso não estão sendo aplicados, de acordo com números mostrados durante a palestra. O Ministério da Saúde previu um orçamento de R$ 28,5 milhões para a Política de Atenção à Saúde do Idoso, mas só aplicou R$ 14,8 milhões. Para o Programa de Direitos do Idoso, da Secretaria dos Direitos Humanos, estavam previstos R$ 5,8 milhões, dos quais só R$ 623 mil foram gastos.

ENVELHECIMENTO ATIVO
Ex-chefe do Programa de Envelhecimento e Saúde da OMS (Organização Mundial da Saúde), Kalache acredita que envelhecer com acesso a serviços, renda e autonomia conferem dignidade a essa fase da vida.
"Otimizar as oportunidades de saúde, de educação continuada e de participação na vida social, de modo a alimentar a qualidade de vida significa promover envelhecimento ativo", afirma. "Todos devem abraçar o envelhecimento, seja qual for a área de atuação, porque essa revolução está aqui para ficar", concluiu.


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Sunday, April 20, 2014

Boston-area researchers develop new delirium severity measure for older adults

A new method for measuring delirium severity in older adults has been developed by researchers from Harvard, Brown, and UMASS. The new scoring system, CAM-S, is based on the Confusion Assessment Method (CAM) and standardizes the measurement of delirium severity for both clinical and research uses. Details of this study are published in Annals of Internal Medicine.
20 april2014-Delirium is defined as the sudden onset of confusion or change in mental status that is often brought about by physical illness, surgery, or hospitalization. Delirium is a common and often costly condition that is a leading complication among older adults who are hospitalized. In fact, studies suggest that delirium in adults ages 65 and older is associated with hospital mortality rates of up to 33%, with estimated annual healthcare costs of more than $182 billion per year.
"Currently, the CAM is the most widely used tool in the world to screen for delirium," says Sharon K. Inouye, M.D., M.P.H., Director of the Aging Brain Center at the Harvard Medical School (HMS)–affiliated Hebrew SeniorLife Institute for Aging Research (IFAR) in Boston and HMS Professor of Medicine. "Our study is the first to develop and test this important new methodology, and to demonstrate the validity and reliability of the CAM-S, a novel approach to measure delirium severity."
The team developed and validated the CAM-S in two groups of patients. The first was a group of 300 patients 70 years of age or older who were scheduled for major surgery as part of the Successful Aging after Elective Surgery (SAGES) study. The second group was part of the Project Recovery study and included 919 older adults (70 or older) who were admitted to the  on the medical service. Researchers developed the CAM-S from the 4-item short form and 10-item long form versions of the CAM, and examined the impact of the CAM-S scores on hospital and post-hospital .
CAM-S scores displayed a strong association with all clinical outcomes including length of hospital stay, nursing home placement, functional and cognitive decline, death, and hospital and post-hospital costs. The study found that length of hospital stay increases with the degree of delirium severity measured by the CAM-S short form from seven days for no delirium symptoms to 13 days for patients with severe delirium; the CAM-S long form showed similar increases in length of stay from six days to 12 days between no and severe symptom groups.
Additionally, mean hospital costs increase with the degree of delirium severity measured by the CAM-S short form from $5,100 for patients without delirium symptoms to $13,200 for those with severe symptoms. Similar results were seen across all levels of the CAM-S long form scores with mean costs increasing from $4,200 to $11,400 across delirium symptom groups ranging from none to severe.
Dr. Inouye concludes, "Our findings demonstrate that the CAM-S provides a new standardized severity measure with high inter-rater reliability, and a strong association with clinical outcomes related to delirium. We believe that this measure holds great promise to improve understanding of the effects of delirium on clinical care, prognosis, pathophysiology, and response to treatment. Ultimately, we hope that this measure will help to prevent the effects of this devastating condition and improve quality of life for older adults."
Provided by Hebrew SeniorLife Institute for Aging Research

Wednesday, April 16, 2014

Calcium score predicts future heart disease among adults with little or no risk factors

With growing evidence that a measurement of the buildup of calcium in coronary arteries can predict heart disease risk, Los Angeles Biomedical Research Institute (LA BioMed) researchers found that the process of "calcium scoring" was also accurate in predicting the chances of dying of heart disease among adults with little or no known risk of heart disease.
16 april 2014Previous studies had found that calcium scores were effective in predicting heart disease among adults with known heart disease risk factors, such as hypertension, diabetes, dyslipidemia, current smoking or a family history of heart disease. The study conducted by LA BioMed researchers examined 5,593 adults with no known heart disease risk or with minimal risk of heart disease, who had undergone coronary artery calcium screening by non-contrast cardiac computed tomography from 1991-2011.
Normally, the coronary arteries don't contain calcium. A buildup of calcium can narrow the arteries to the heart and lead to a heart attack. The screening process results in a calcium score indicating the amount of calcium in the plaque lining the walls of the coronary arteries.
Among the adults in the study, even those with low coronary artery calcium scores of 1-99 were 50% more likely to die of heart disease than adults with a calcium score of zero. Adults with moderate scores of 100-399 were 80% more likely to die from heart disease than those with a score of zero, and those with scores of 400 or more were three times more likely to die from heart disease, when compared to adults with no calcified plaque buildup, or a score of zero.
"This long-term study builds on previous research conducted at LA BioMed and other institutions that have proven the effectiveness of coronary artery calcium screening in predicting heart disease risks," said Matthew J. Budoff, MD, one of the LA BioMed researchers who conducted the study. "Normally, calcium scoring is only recommended for patients with known heart disease risks. These findings suggest that calcium scoring can be an effective tool for assessing heart disease risks in adults with no known risk factors so that they can make the lifestyle and other changes that can help them avoid heart disease in the future."
Dr. Budoff and Rine Nakanishi, MD, PhD, presented these findings at ACC.14, the annual scientific session of the American College of Cardiology in March, along with other researchers whose studies also found coronary artery calcium screening accurately predicted the risk of future heart disease.
Provided by Los Angeles Biomedical Research Institute at Harbor

Tuesday, April 15, 2014

For sick, elderly patients, surgical decision making 'takes a village'

For sick, elderly patients, surgical decision making 'takes a village'
Surgical decision making for sick, elderly patients should be orchestrated by a multidisciplinary team, including the patient, his or her family, the surgeon, primary care physician, nurses and non-clinicians, such as social workers, advocates Laurent G. Glance, M.D., in a perspective piece published in the New England Journal of Medicine.
15 april--For this group of patients, surgery can be very risky. Glance, professor and vice-chair for research in the Department of Anesthesiology at the University of Rochester School of Medicine and Dentistry believes a more patient-centered, team-based treatment approach would lead to higher quality care that matches the values and preferences of the sickest patients.
Usually, patients undergo a one-on-one consultation with their surgeon, who is frequently solely responsible for most of the decision making and management surrounding a possible surgical procedure. However, this traditional approach has potential pitfalls. For example, patients may not always be presented the full range of treatment options, such as medical treatment, less invasive surgical options, or watchful waiting.
"Evaluating treatment options, formulating recommendations and articulating the benefits and risks to patients comprehensively require more than a well-informed or experienced surgeon," noted Glance, who is also a professor of Public Health Sciences and a cardiac anesthesiologist at UR Medicine's Strong Memorial Hospital, in addition to holding an adjunct appointment at RAND Health.
Consultation with a team of medical personnel, on the other hand, helps patients better understand the benefits and risks of each option, the likelihood of a good outcome and the risks of complications, enabling them to make informed decisions that are driven by what's most important to them and their family.
According to the article, one-third of elderly Americans have surgery in the last 12 months of their lives, most within the last month. But, three-quarters of seriously ill patients say they would not choose if they knew they are likely to have severe cognitive or functional complications afterward.
Currently, such teamwork occurs mostly on an ad hoc basis, says Glance. In the future, multidisciplinary teams could meet regularly – in person or virtually – to discuss high-risk cases. By limiting the focus of such efforts to frail, elderly patients or to those with complex conditions who stand to benefit most from this multidisciplinary approach, healthcare organizations could minimize the costs involved. However, Glance acknowledges that gaining acceptance of this shift in the current culture of surgical decision making may not be straightforward.
Provided by University of Rochester Medical Center

Saturday, April 12, 2014

Exposure Therapy
for Fears and Phobias

12 april--Exposure Therapy has been shown to be the most effective anxiety treatment for people with many anxiety disorders. You might already know that it involves practicing with what you fear, in order to become less afraid. But how does it work?
Exposure Therapy helps you retrain your brain. It's not just about "getting used to" the fear. It's about retraining your brain to stop sending the fear signal when there isn't any danger.
People struggle against anxiety attacks and phobias because they recognize that their fears are exaggerated and illogical. They try hard to talk themselves out of the fear.
But that doesn't help. So they end up trying to avoid the fear, and that, unfortunately, just strengthens it.
Exposure Therapy will help you retrain your brain to let go of phobias, anxiety attacks, and other forms of anxiety disorders.
Let's see how Exposure Therapy works.

Fight or Flight

When your brain gets a signal of danger, it triggers an immediate response, the familiar Fight or Flight response. That's a good thing, because when we face danger, we need to react quickly and powerfully.
Humans evolved in a different world than the one we inhabit today. It was a world full of predators, without police or deadbolt locks. Our main job was to get enough to eat each day without becoming food for somebody else. We needed a good emergency alert system to keep us out of the jaws of predators.
If we had relied on the thinking, intellectual part of our brain, called the cerebral cortex, to keep us safe, we'd be extinct. It's too slow. It's good for writing a speech, and figuring out your income tax, but not for making snap decisions about danger.
The part of your brain that handles these Fight or Flight responses is very different from the part of the brain you're most familiar with.

The Amygdala

The Amygdala, a little almond shaped part of your brain, is what makes these Fight or Flight decisions. The Amygdala works quickly, without your conscious awareness, because speed is vital in protecting against threats. You only find out what the Amydgala did when you feel its effects in your body (all the familiar panic sensations) and in your behavior (duck, run, escape).
Whenever we make a decision, there are two possible kinds of errors. One is a false positive. If you decide there's a tiger hiding in the tall grass, when there isn't one, that's a false positive. When you make a false positive error, you get afraid in the absence of danger, but you don't get eaten.
The second type is a false negative. If you decide there's no tiger hiding in the tall grass when there really is one, that's a false negative. When you make this false negative error, you feel okay, but you're gonna get eaten.
Your Amygdala doesn't care how many times it scares you unnecessarily. It just aims to keep you alive. It doesn't want to make any false negative mistakes.
If you experience phobias and anxiety attacks, and want to overcome them, you need a form of anxiety treatment which will retrain this part of your brain. The most direct and systematic way to do that is Exposure Therapy.

How Your Amygdala Works

Always Watching

Your Amygdala is always watching, passively, in the background, for some sign of danger. When it sees one, true or false, it presses the "fight or flight" button and fills you with fear. When the danger is real, that's a good thing. But your Amygdala works like it's still 27,000 B.C., and will often make the mistake of seeing danger when there's none.

It Learns by Association, not Reason or Logic

When you run away from whatever the apparent danger is, the Amygdala stands down and goes back to quietly watching. If you ran away from a mugger, that's a good thing. But if you ran away from a grocery store, or a dog on a leash, that's a bad thing. Now your Amygdala will be conditioned to see the grocery store or the dog as dangerous, and will make you afraid next time you see one.
The Amygdala learns by association. It associates the crowded store, or the dog, with danger. It doesn't learn by conscious thought. This is why you can't simply talk yourself out of a phobia or anxiety attack. The fear memory is stored as a conditioned fear, and can only be relieved by more conditioning, not discussion or reason.

It only Learns When You're Afraid

The Amygdala only learns when it's fully activated, when it spots something it considers dangerous. It only forms new memories and associations, new lessons, when you've become afraid. The rest of the time it's on autopilot, passively watching.
Do you see what this means? If you stay away from what you fear, your Amygdala will keep on "believing" the same old mistakes, without a chance to learn anything new.

How Can You "Talk" to Your Amygdala?

Your Amygdala only learns from experience. If you flee the scene every time you have an anxiety attack, your Amygdala learns that you should leave to be safe.
How can you get your Amygdala to learn something new? You have to activate it by exposing yourself to a trigger that gets you afraid. If you have a dog phobia, that would be a dog. If you have anxiety attacks on subways (or highways), you need a subway (or a highway). And you need to stay there with that fear until it gets a lot lower.
That gives your Amygdala the chance to learn that it got all worked up about nothing. That way, it can learn that dogs (or highways) aren't the threat that it had been conditioned to believe. And, with repetition, it will develop a new memory, one that lets you get on with your life without being disrupted by phobias and anxiety attacks.

Retraining Your Amygdala

That's how Exposure Therapy works. Exposure Therapy retrains your Amygdala.
You don't have to do this radically and quickly. What you need to do is to continually arrange to activate your Amygdala by exposing yourself to what you fear, and then stay in place, making sure that the fear leaves before you do. You can use a variety of coping steps to help you do that, or you can just "float", as Claire Weekes called it, and wait for the fear to subside. Either way, Exposure Therapy will enable you to retrain your Amygdala with new learning in ways it can absorb.


Monday, April 07, 2014

Coronary calcium scores may help predict risk of death in patients without family history of heart disease

Coronary calcium scores may help predict risk of death in patients without family history of heart disease


Current guidelines only recommend coronary artery calcium (CAC) scoring for low-risk patients if they have a family history of early heart disease.
07 april 2014—A new Emory University study shows that coronary artery calcium (CAC) scoring, a type of low-dose CT scan, accurately predicts the risk of dying over the next 15 years in patients with and without a family history of early heart disease. The findings were presented this week at the American College of Cardiology meeting in Washington, D.C.
A coronary artery calcium scan is a simple, non-invasive test that uses low-dose X-rays to measure the amount of calcium in plaque on the walls of the arteries of the heart.
"While we found that CAC scoring is accurate at predicting the risk of death over a 15-year period in all patients, this is the first study to show it is most accurate in those without a family history of early heart disease," says Joseph Knapper, MD, an internal medicine resident at Emory University School of Medicine.
"This suggests there may be a benefit to expanding CAC testing to all low-risk patients, regardless of their family history, allowing patients to learn about their risks sooner and take actions to decrease them."
Current guidelines only recommend CAC scoring for low-risk patients if they have a family history of early heart disease.
Knapper and his colleagues followed 6,300 patients with a family history of early heart disease, and about 2,800 patients without a history. Each study participant underwent a CT scan to receive a CAC score and was interviewed to establish their risk factors for heart disease (i.e. cigarette smoking, high blood pressure, diabetes, etc.). Researchers tracked the patients for 15 years and recorded deaths that occurred in that time period, regardless of the cause.
They found that patients with a higher CAC score were more likely to have died over the 15-year period, even after controlling for other risk factors such as smoking and high blood pressure. Most importantly, the highest risk CAC scores (greater than 1,000) showed a nearly eight times higher risk of death compared to the lowest risk score in patients without a family history, whereas in those with a family history the risk was increased less than four-fold.
Knapper says further research, including cost analysis, is needed before a recommendation could be made to expand CAC screening guidelines.
Provided by Emory University

Saturday, April 05, 2014

Calcium supplementation does not increase coronary heart disease concludes new study

Researchers presenting at the World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases showed the results of a meta-analysis of randomized controlled trials of calcium supplements. The results do not support the hypothesis that calcium supplementation, with or without vitamin D, increases coronary heart disease or all-cause mortality risk in elderly women.
05 april 2014--The results of a study presented today at the World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases do not support the hypothesis that calcium supplementation, with or without vitamin D, increases coronary heart disease or all-cause mortality risk in elderly women.
The investigators, from centres in Australia, Denmark and the USA, undertook a meta-analysis of randomized controlled trials of calcium supplements with or without vitamin D. They searched for two primary outcomes: coronary heart disease and all-cause mortality verified by clinical review, hospital record or death certificate. The Cochrane Central Register of Controlled Trials, MEDLINE, and EMBASE databases were searched from January 1, 1966 – May 24, 2013 for potentially eligible studies, reference lists were checked, and trial investigators were contacted where additional data was required. Eligibility criteria included randomized controlled trials of calcium supplementation with or without vitamin D with events with a mean cohort age >50 years. Trial data were combined using a random-effects meta-analysis to calculate relative risk of heart disease events in participants supplemented with calcium.
Of the 661 potentially eligible reports, 18 met the stringent inclusion criteria, contributing information on 63,564 participants with 3,390 coronary heart disease events and 4,157 deaths from any cause. Five trials contributed coronary heart disease events with pooled relative risk (RR) for calcium of 1.02. And 17 trials contributed to all-cause mortality data with pooled RR for calcium of 0.96. The meta-analysis showed that calcium supplementation with or without vitamin D does not increase coronary heart disease or all-cause mortality risk in elderly women.
More information: OC34 The effects of calcium supplementation on coronary heart disease hospitalisation and death in postmenopausal women: a collaborative meta-analysis of randomised controlled trials. J. R. Lewis, K. L. Ivey, S. Radavelli-Bagatini, L. Rejnmark, J. S. Chen, J. M. Simpson, J. M. Lappe, L. Mosekilde, R. L. Prentice, R. L. Prince. Osteoporos Int. Vol 25, Suppl. 2, 2014
Provided by International Osteoporosis Foundation

Saturday, March 22, 2014

Cuba gives doctors big pay raise—to $64 a month

Cuba's doctors got a big pay raise Friday —to 64 dollars a month, the official Communist Party newspaper Granma said.
22 mar 2014--The hike in pay from $25 a month was to reward health professionals for being the country's top source of hard currency export earnings.
President Raul Castro last month rejected pay increases for other state workers, but said they were justified for doctors, dentists and nurses "because at the moment the country's main income is due to the work of thousands of doctors overseas."
Some 50,000 Cuban doctors and health specialists work in 66 countries.
They bring in $8.2 billion a year into state coffers. The value of Cuban exports, by comparison, totals only $5 billion a year.
Cuban doctors earn far more serving overseas than they do at home, but the lion's share of their salaries goes to the government.
In Brazil last month, a Cuban doctor asked for asylum after learning that she would receive only $1,000 dollars of her $4,000 salary—with the balance going to Cuban authorities.
Take home pay for the more than 11,000 Cuban doctors in Brazil was raised to the equivalent of $1,245 after the incident.
Granma said the  hike announced Friday would "contribute to the stability and quality of medical services to the public, while also meeting international commitments."
© 2014 AFP

Friday, March 21, 2014

One million people commit suicide each year: WHO

One million people die by their own hand each year, accounting for more deaths than wars and murders put together, the World Health Organisation said Friday, calling for urgent action to address the problem.
22 mar 2014--"Data from the WHO indicate that approximately one million people worldwide die by suicide each year. This corresponds to one death by suicide every 40 seconds," the organisation said in a report launched ahead of the World Suicide Prevention Day on Monday.
And while the number of deaths by suicide is staggering, the number of attempts each year is 20 times higher, the WHO said, pointing out that five percent of people in the world try to kill themselves at least once during their lifetime.
And the problem is getting worse, the organisation said, insisting that "given the magnitude of the public health problem of suicidal behaviours", urgent action was needed.
"As suicide is largely preventable, it is imperative that governments, through their health, social and other relevant sectors, invest human and financial resources in suicide prevention," the report said.
According to Dr. Shekhar Saxena, who headed the team behind the report, suicide rates have risen sharply in some parts of the world in recent years, with some countries seeing their rates jump by as much as 60 percent.
"Although suicide continues to remain a serious problem in high income countries, it is the low and middle income countries that bear the larger part of the global suicide burden," the report said, adding: "It is also these countries that are relatively less equipped to prevent suicide".
The highest documented suicide rates can be found in Eastern European countries like Lithuania and Russia, while they are lowest in Latin America, WHO said.
The United States, Western European countries and Asia fell in the middle of the range, the report showed, but stressed that statistics are not available for many countries in Africa and South-East Asia.
Globally, suicide is meanwhile the second cause of death worldwide among 15-19 year-olds, with at least 100,000 adolescents killing themselves each year, according to the study.
Among adults, the suicide rate is highest among those aged 75 and older, the WHO said, pointing out that "elderly people are likely to have higher suicide intent and use more lethal methods than younger people, and they are less likely to survive the physical consequences of an attempt".
The report also showed that men were three times more likely to commit suicide, but that three times as many women as men attempted to kill themselves.
"The disparity in suicide rates has been partly explained by the use of more lethal means and the experience of more aggression and higher intent to die, when suicidal, in men than women," it explained.

Evidence supports existence of mid-life crises

It's official: mid-life crises do exist
21 mar 2014—Social economists from the University of Melbourne have confirmed the age-old suspicion of a dip in human happiness during middle age.
Past evidence for "mid-life crises" have come from cross sectional data. That is, by comparing surveys of different people's happiness at different ages.
But now, for the first time, researchers have tracked the happiness levels of thousands of people across three countries over multiple decades.
"We have identified a clear 'U-shape' in human wellbeing," said researcher Dr Terence Cheng, from the University of Melbourne's Institute of Applied Economic and Social Research.
"The jury's now in. People really do experience mid-life crises."
The study—Longitudinal Evidence for a Midlife Nadir in Human Well-being—was completed in partnership with the University of Warwick and the London School of Economics, and published as a working paper by the German based Institute for the Study of Labor.
It used nationally representative survey data from Australia, Britain and Germany.
It's official: mid-life crises do exist
"What is interesting is the consistency of the results in all of the three countries we examined. Human happiness hits the lowest point around the ages of 40 to 42", Dr Cheng said.
"Indeed all the more intriguing is that the U-shape pattern has been recently observed in research on great apes. Perhaps we are more similar than we think?"
Dr Cheng said tracking changes in happiness over time makes the study more accurate.
"We looked at the well-being of 'Mr Jones' at age 35, 45, 55, and so on. This is important as the U-shape finding therefore does not arise from variations across different people, but rather within individuals," Dr Cheng adds.
More information: The study, "Longitudinal Evidence for a Midlife Nadir in Human Well-being," is available online: ftp.iza.org/dp7942.pdf
Provided by University of Melbourne

Thursday, March 20, 2014

High-protein diets: Bad for the middle-aged, good for the elderly

Consuming high levels of protein - particularly animal protein - is a bad strategy if you're at midlife and aiming to live into old age, new research finds. But a study out Tuesday reveals that in older age, fortifying one's diet with more protein-rich foods appears to be a formula for extending life.
20 mar 2014--An article published in the journal Cell Metabolism says that, over an 18-year study period, middle-aged Americans who had the highest consumption of protein were more than four times as likely to die of cancer or diabetes, and twice as likely to die of any cause, than those whose diets were lowest in protein.
But a high-protein diet had the opposite effect on Americans 66 and older, a group of American and Italian researchers found. Those whose diets were highest in protein were 60 percent less likely to die of cancer and 28 percent less likely to die of any cause than were those whose protein intake was lowest.
"Your stage in life matters," said biogerontologist Valter Longo, director of the University of Southern California's Longevity Institute and lead author of the paper, which explores the role of dietary protein from the cellular level to the population level. "Some have said for years that proteins are bad. That's half right and half wrong."
Tapping a national database of 6,381 Americans' health and nutrition behaviors, Longo's team found that in people between the ages of 50 and 65, following a diet in which protein accounted for 20 percent or more of daily calories consumed increased the risk of death during the 18-year study period to levels comparable to the effect of smoking cigarettes.
Whether the remainder of those younger individuals' diet was dominated by fat or carbohydrates made no difference to the outcome. But the source of the protein mattered a great deal: for those whose sources of protein were heavily plant-based - nuts and legumes - the increased risk of dying of cancer declined and the increased risk of all-cause mortality disappeared altogether.
Among the study's older subjects, by contrast, the source of proteins was less important. What was important, said Longo, appeared to be that those entering a period of growing frailty reduced their loss of weight and muscle mass with a higher intake of a nutrient that helps sustain and build both.
The article by the U.S.-Italian team is the culmination of two decades of study that has coaxed the researchers to look for clues well outside the lab: Longo and his team have studied the dietary habits of a little town in Italy with a high concentration of centenarians, and have traveled to Ecuador to gather information on an exceptionally long-lived family congenitally deficient in a growth hormone linked to cancer.
The findings of Longo's team are in line with mounting research on the hazards of heavy consumption of red meats and the protective effects of plant-based nutrients. But unlike many large-population studies that have found links between poor health outcomes and animal protein consumption, the current study identified the potentially pivotal role that a hormone called insulin-like growth factor-1, or IGF-1, plays in driving age-related diseases such as cancer.
In a subset of the study's human subjects who submitted their blood for analysis, as well as in laboratory mice, Longo's team found that heavy protein consumption in middle age drove up levels of IGF-1. In the group's rodent experiments, higher IGF-1 levels - whether induced by high protein consumption or genetic engineering - promoted rapid cancerous growth when the researchers implanted 20,000 cancer cells under the animals' skin: 100 percent of these mice developed tumors.
Among mice that were fed a low-protein diet through middle age - and which therefore had lower IGF-1 levels - tumor formation was 10 percent to 30 percent lower.
At the same time, the researchers uncovered evidence that older mice were less able to absorb or process proteins. When they were fed high-protein diets, the older mice tended to maintain or increase their weight - a factor that appeared to keep them from becoming frail. By contrast, older mice fed a low-protein diet lost weight; that, says Longo, appeared to make them more vulnerable to diseases of aging.
IGF-1, produced largely in the liver, is essential to normal human growth and to the process of cell replacement after injury . But it is also implicated in a wide range of disorders associated with overgrowth and cell proliferation, including heart enlargement, the runaway cell growth common to all cancers, and obesity.
But while IGF-1's role in promoting tumor growth has long been recognized, its link to a high-protein diet appears to be a new.
"People will say, 'Here we go again: First you attack the fats, then you attack the carbohydrates, now it's the protein,' " Longo said. But over 20 years of research linking heavy protein consumption to diseases of aging, and eventually to higher IGF-1 levels, he said, "we never changed our mind": Americans' protein-packed diets "are hurting them in a major way."

Sunday, March 09, 2014

Aging population leading to more arrhythmia diagnoses

Aging population leading to more arrhythmia diagnoses
Craig Wilkins was feeling tired, breathless and in need of a vacation. Although he attributed his tiredness to too many long and hectic hours at the office, the 56-year-old decided to see his family doctor in Cary, N.C., before leaving for a family trip.
09 mar 2014--Craig was otherwise healthy and had no history of heart disease, but his doctor discovered he had atrial fibrillation, a condition that can cause the heart to race, sometimes beating hundreds of times in one minute. These episodes, called tachycardias, were making Craig feel fatigued.
An estimated 12 million people will have atrial fibrillation by 2050, according to the Centers for Disease Control and Prevention. Atrial fibrillation is a type of arrhythmia that causes the heart to beat irregularly. It can be genetic or caused by scar tissue on the heart, diabetes, high blood pressure or stress. An aging population, an increased survival rate following heart attacks and rising rates of heart disease mean more Americans will be entering their 60s and 70s with arrhythmias, which are a leading cause of stroke and cardiac events, and can dramatically alter a person's quality of life.
For some, atrial fibrillation is annoying but not life threatening. For Craig, the condition had gone undetected for so long that he had developed congestive heart failure. "I was shocked when the doctor told me how serious it was," says Craig.
Initially, Craig was given a course of blood thinners to prevent clots that could be lethal, followed by a cardioversion, an electrical shock to the heart, to reset the heart beat back to normal. Though this worked initially, his heart eventually returned to the abnormal heartbeat. After several attempts at cardioversion, Craig's doctor tried anti arrhythmia medication.
"They put me in the hospital and used a powerful anti arrhythmia drug," says Craig, who stayed in the hospital for three days as doctors watched his heart.Two days after he was released, he returned to work and passed out at his desk.
An estimated 12 million people will have atrial fibrillation by 2050, according to the Centers for Disease Control and Prevention. Atrial fibrillation is a type of arrhythmia that causes the heart to beat irregularly. It can be genetic or caused by scar tissue on the heart, diabetes, high blood pressure or stress. An aging population, an increased survival rate following heart attacks and rising rates of heart disease mean more Americans will be entering their 60s and 70s with arrhythmias, which are a leading cause of stroke and cardiac events, and can dramatically alter a person's quality of life.
Aging population leading to more arrhythmia diagnoses
Andy Kiser, MD (left), with Paul Mounsey, MD Courtesy Donn Young
For some, atrial fibrillation is annoying but not life threatening. For Craig, the condition had gone undetected for so long that he had developed congestive heart failure. "I was shocked when the doctor told me how serious it was," says Craig.
Initially, Craig was given a course of blood thinners to prevent clots that could be lethal, followed by a cardioversion, an electrical shock to the heart, to reset the heart beat back to normal. Though this worked initially, his heart eventually returned to the abnormal heartbeat. After several attempts at cardioversion, Craig's doctor tried anti arrhythmia medication.
"They put me in the hospital and used a powerful anti arrhythmia drug," says Craig, who stayed in the hospital for three days as doctors watched his heart.Two days after he was released, he returned to work and passed out at his desk.
Dr. Mounsey performed a cardiac ablation on Craig's heart. In an ablation, doctors thread catheters through the arteries to the heart and use radiofrequency to destroy the damaged heart tissue causing the atrial fibrillation. Ablations are often successful, but in Craig's case, a flutter continued even after the procedure. A second ablation was performed, but the location of where the flutter was originating meant ablation could not correct it.
Dr. Mounsey then collaborated with Dr. Kiser to perform the Convergent Procedure.
Traditionally, surgeons, like Dr. Kiser, have created scar pat- terns to disrupt the circuitry that causes atrial fibrillation arrhythmia, while electrophysiologists, like Dr. Mounsey, have performed ablations. With the Convergent Procedure, Drs. Mounsey and Kiser work side by side using miniature cameras, small catheters and electrodes to map out an individualized pattern that will work to reestablish normal rhythms in each patient.
Drs. Mounsey and Kiser have been performing the procedure since 2011, and they recently completed their 100th surgery. They have an 80 percent success rate, which is extremely high for complex arrhythmias.
Five years after Craig's initial atrial fibrillation diagnosis and a year and a half after having the Convergent Procedure, he says his health is excellent. "I can't believe how bad I used to feel," says Craig. "I have energy and a desire to do things now."
Craig felt so good, he left his IT job behind and made a career change, opening The Meat House, a neighborhood butcher and grocery franchise in Raleigh and Cary.
Craig's case is a good example of the patients who will benefit most from the UNC Heart & Vascular Network. Patients who live in the Raleigh area and their primary care physicians will have access to a group of cardiologists and services in their local communities, and for the most complex cases, they will have access to the leading research, technology and specialty care available at UNC Health Care.
With the creation of this new network, Drs. Kiser and Mounsey will work alongside Sidharth Shah, MD, a cardiac electrophysiologist in Raleigh. Dr. Shah performs cardiac ablations and works with cardiac devices, such as pacemakers and cardio defibrillators, and his work is closely associated with research opportunities and clinical trials.
"In the past we had to send our patients who were in the UNC or Rex system to other centers," says Dr. Shah. "Now, we can keep them close to home."
Provided by University of North Carolina at Chapel Hill School of Medicine

Thursday, March 06, 2014

How the internet is transforming our experience of being ill

The last decade has seen a remarkable shift in how people use the internet in relation to their health and it is now talked of as a routine feature of being ill.
06 mar 2014--Professor Sue Ziebland, Director of the Health Experiences Research Group, based in the Nuffield Department of Primary Health Care at the University of Oxford, will share these findings with health practitioners and researchers at the South West Society for Academic Primary Care (SW SAPC) meeting hosted by the Centre for Academic Primary Care at the University of Bristol, today [Thursday 6 March].
This study examined interviews with patients conducted between 2001 and 2013 and explored how people talked about the internet, capturing changing attitudes towards the use of the internet for health across the last decade.
In the early 2000's people who sought health information online saw themselves as particularly engaged, expert and activated patients. By 2013 the web had become an almost routine part of many people's experience of health and illness. The internet has transformed how people make sense of and respond to symptoms, decide whether to consult, make treatment choices, cope with their illness and connect to others.
The study found that people want more than just information online, they also seek reflections, insights and practical advice from other patients. Every year millions of people use sites such as Oxford's http://www.healthtalkonline.org to learn about their health issues from other patients. Film, animations, sound, pictures and personal experiences online make health information more digestible for people from all backgrounds. By helping people to learn about their condition, prepare for consultations and demonstrate to doctors their interest and involvement, the web may even help to undermine some health inequalities.
Increasingly doctors are aware of this and recommend useful sites to their patients yet, even in 2013, patients were reluctant to talk to their doctors about what they find online, fearing that such revelations might damage their relationship with their doctor.
Professor Sue Ziebland said "GPs and nurses who recognise that people are using the internet when they are ill can support and discuss the information with their patients; those who do not recognise this shift can unwittingly undermine and patronise their patients."
Provided by University of Bristol

Monday, March 03, 2014

Developing an intelligent avatar to help UK's aging population

The University is taking a leading role in a ground-breaking project to support the UK's aging population through the use of responsive and interactive avatars.
03 mar 2014---Kent's Centre for Child Protection is heading a consortium of partners developing a project, known as Responsive InTeractive Advocate (RITA), which has won a share of £2.4m in funding from the UK's innovation agency, the Technology Strategy Board (TSB).
The RITA project is one of six born of a national Technology Strategy Board initiative aimed at developing new cost-effective ways of helping elderly people to continue to live comfortably and independently in their own homes if they want to.
Kent is working with the University of Portsmouth's School of Creative Technologies and two companies - Affective State and We Are Snook - in the consortium, with each partner responsible for a different element of the project.
Dr Jane Reeves, Co-Director of the Centre for Child Protection, said: 'There is a major debate about how we provide care for vulnerable people across all age-groups and this project is seeking to meet one of our biggest challenges, which is ensuring older adults can remain independent for as long as possible.
'Although this project is at an early stage, with a number of technical, moral and ethical issues to be addressed, the development of RITA in the form of a humanised avatar could revolutionise how an individual's personal, social emotional and intellectual needs are met in the future.
'RITA would exist as a digital champion, an advocate in the form of an avatar, providing a friendly interface between the individual, family, friends, professions and services.'
The avatar might appear as a figure on a television screen or a tablet computer or could even be a holographic display. It could monitor heart rate and blood pressure, remind people to take medication and would know if they had fallen over or were in pain and alert the doctor or the emergency services. It would be able to analyse their speech, movement and facial expression to detect their mood and respond accordingly. The system would not require computer literacy and would be no more challenging to operate than switching on a television.
Kent's Centre for Child Protection has an international reputation as a centre of excellence and innovation in training, research and practice for the full range of professionals involved in . It sees this project as an opportunity to become involved in developing an innovation for the future that could provide significant benefit across the life course.
Dr Reeves added: 'Of course, these developments have enormous ethical and legal implications but we will explore these fully as the project develops.'
The University of Portsmouth will focus on developing the interactive avatar, while Winchester-based company Affective State will work on sensing and forecasting emotional well-being and Glasgow-based We Are Snook focus on the user experience design.
The funding competition, called the Long Term Care Revolution, is funded through the Small Business Research Initiative scheme, which connects public sector challenges with innovative ideas from industry. The RITA project has been awarded £500K.
Iain Gray, Chief Executive of the Technology Strategy Board said: 'This is an expanding market and we need to radically rethink our approach to long-term care provision, providing options that will enable people to live with more dignity and autonomy.
'We focus innovation activity on areas where we think it can make the biggest difference. Late life care is often regarded as an economic liability but it can actually be an engine for economic growth.'
Provided by University of Kent

Saturday, March 01, 2014

Personalized medicine has finally arrived—or has it?

As the price for decoding a person's DNA keeps dropping, expectations for personalized medicine based on specific genetic profiling rise. But translating an individual's genetic data into finely tailored medical treatments still faces major challenges, explains a new article in Chemical & Engineering News (C&EN), the weekly magazine of the American Chemical Society.
01 mar 2014--Rick Mullin, senior editor at C&EN, notes that advances in DNA sequencing have allowed researchers to design some therapies, particularly in the cancer realm, for patients with certain genetic traits. As the technology for reading people's genes improves and drops even further in cost, more progress is on the horizon. The U.S. Food and Drug Administration, the government body responsible for approving pharmaceuticals for commercialization, supports these efforts. With the stars seemingly aligned, some industry experts have declared that the age of personalized medicine has arrived. So why do others claim that victory is still a long way off?
The article points out that when pharmaceutical labs launched their search for new drugs based on genomics more than 15 years ago, the focus was almost exclusively on DNA sequences. But now researchers have realized that for personalized medicine to truly take hold, they need to also pay attention to individuals' health histories, their environments and how their genes actually translate into physical traits. This requires a shift in thinking, plus closer ties between the research and clinical sides, and ultimately, insurers. But perhaps the tallest barrier is cultural—an attitude among some in the health care industry to simply continue business as usual.
Provided by American Chemical Society