Beta carotene, vitamin A, and vitamin E supplements were associated with increased mortality in a large meta-analysis and systematic review reported in today's JAMA.
Researchers examined randomized, controlled trials of antioxidants used for primary or secondary disease prevention. When the researchers focused in on the trials that used high-quality methodology -- 47 studies comprising about 180,000 patients -- they found recipients of supplements had increased mortality compared with controls (relative risk, 1.05). Used singly or in combination with other supplements, beta carotene, vitamin A, and vitamin E increased mortality in high-quality trials. Vitamin C did not have a significant effect on mortality.
The authors conclude: "Our results extend previous reviews and guidelines, suggesting that antioxidant supplements may not be beneficial."
http://www.medpagetoday.com/PrimaryCare/DietNutrition/dh/5152
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