Sunday, March 25, 2007

Japan experts link osteoarthritis to gene variant

HONG KONG (Reuters) - Researchers in Japan have identified a gene variant that may be responsible for osteoarthritis, a painful condition in the joints that affects more than 200 million people worldwide.
Osteoarthritis usually happens in old age, when there is a breakdown and loss of cartilage in the joints, leading to swelling and pain, and restricting mobility.
The scientists said in the journal Nature Genetics they had analyzed DNA from two groups of Japanese patients with hip osteoarthritis and found that the gene variant showed up more frequently in them than in a group that did not suffer from the disease.
The same variant was also found to be significantly more frequent in both Japanese and Chinese individuals suffering from osteoarthritis of the knee, they wrote.
"Association (between osteoarthritis and the variant gene) was found in Japanese populations and the association was replicated in a Chinese population," lead researcher Shiro Ikegawa at the SNP Research Center in Tokyo told Reuters.

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