April 12, 2007 — A study shows individuals with type 2 diabetes have a significantly increased risk of developing amnestic mild cognitive impairment (MCI), a condition widely acknowledged as a transitional state between normal cognitive functioning and Alzheimer's disease (AD).
In a longitudinal study appearing in the April issue of the Archives of Neurology, elderly individuals with type 2 diabetes were found to be at greater risk for MCI overall and for amnestic MCI impairment specifically compared with their counterparts without diabetes.
"In our analyses, diabetes was related to a higher risk of amnestic MCI even after adjusting for stroke and vascular risk factors, which suggests that the association between diabetes and amnestic MCI is independent of cerebrovascular disease," José A. Luchsinger, MD, from the Columbia University Medical Center in New York, and colleagues write.
Conversely, the authors note, the association between diabetes and nonamnestic MCI lessened and became nonsignificant after adjustment for stroke and vascular risk factors. This finding suggests cerebrovascular disease may mediate the relation between diabetes and nonamnestic MCI, the authors say.
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